Radioimmunotherapy using .alpha.-particles emission

Details Radioimmunotherapy using .alpha.-particles emission Radioimmunotherapy using .alpha.-particles emission

1991-02-19

1993-09-21

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, A61K 4300, C07F 1700

Patent

active

052466914

ABSTRACT:
The present invention relates to the use of Actinium or one of its daughters in radioimmunotherapy. Also provided are immunoconjugates comprising an isotope, a chelating agent and a slowly localizing antibody. The invention also includes pharmaceutical compositions comprising said immunoconjugates, as well as such compositions comprising one or more scavenging agents. The compositions according to the invention are particularly useful for the treatment of micrometastases in adjuvant therapy, as well as for treatment of localized tumors.

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"Preparation of .sup.224 Ra for Therapy of Ankylosing Spondylitis", Delikan Health Physics, vol. 35, No. 1, pp. 21-24 (1978).

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