Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1993-09-16
1997-01-21
Wu, Shean C.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
4241441, A61K 5110
Patent
active
055957218
ABSTRACT:
Methods for the treatment of lymphoma by adminstration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4361544 (1982-11-01), Goldenberg
patent: 4444744 (1984-04-01), Goldenberg
patent: 4921690 (1990-05-01), Beatty et al.
patent: 5034223 (1991-07-01), Abrams et al.
Kaminski et al., "131-I Anti-B1: Initial Clinical Evaluation in B-Cell Lymphoma," Antibody Immunoconjug. Radiopharm., vol. 4, No. 1 (1991), abstr. # 144.
Buchsbaum et al., Cancer Research, vol. 52, pp. 6476-6481 (1992).
Buchsbaum et al., Cancer Research, vol. 52, pp. 637-642 (1992).
Macklis et al., Int. J. Radiation Oncology Biol. Phys., vol. 27, pp. 643-650 (1993).
Macklis et al., Radiation Oncology Biol. Phys., vol. 24, Supplement 1, Abstract 101, pp. 184 (1992).
Letvin et al, Nucl. Med. Biol., vol. 14, No. 2, pp. 99-105 (1987).
Ettinger et al, Cancer Treatment Reports, vol. 66, No. 2, pp. 289-297 (1982).
Weinstein et al, Science, vol. 218, pp. 1334-1337 (1982).
Stashenko et al, The Journal of Immunology, vol. 125, No. 4, pp. 1678-1685 (1980).
Order et al, Int. Journal Radiation Oncology Biol. Phys., vol. 6, pp. 703-710 (1980).
Stanley E. Order, Int. J. Radiation Oncology Biol. Phys., vol. 8, pp. 1193-1201 (1982).
Eary et al, The Journal of Nuclear Medicine, vol. 31, No. 8, Aug. 1990, pp. 1257-1268.
Press et al, Journal of Cinical Oncology, vol. 7, No. 8, Aug. 1989, pp. 1027-1038.
Kaminski et al, The New England Journal of Medicine, vol. 329, No. 7, Aug. 1993, pp. 459-465.
Goldenberg et al, Journal of Clinical Oncology, vol. 9, No. 4, Apr. 1991, pp. 548-564.
DeNardo et al, Cancer Research (Suppl.) 50, 1014s-1016s, Feb. 1990.
Parker et al, Cancer Research (Suppl.) 50, 1022s-1028s, Feb. 1990.
Press et al, Blood, "Monoclonal Antibody 1F5 (Anti-CD20) Serotherapy of Human B Cell Lymphomas," vol. 69, pp. 584-591 (1987).
Eary et al, Abstract "Treatment of B-Cell Lymphoma with I-131 Labeled Murine Monoclonal Antibodies," vol. 29, No. 5 (1988).
Cancer Research Weekly, "Immunomedics Reports on Lymphoma Imaging and Therapy Progress at Cancer Conference," (1993).
Press et al, (Abstract), "Radiolabeled Antibody (RAb) Therapy of Relapsed B Cell Lymphomas," pp. 1077 (Apr. 1992).
Macklis et al, Abstract 39 from Fourth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer (Sep. 1992).
Kaminski et al, Abstract 57 from Fourth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer (Sep. 1992).
Czuczman et al, Abstract 55 from Fourth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer (Sep. 1992).
Butchko Gregory M.
Glenn Stephan D.
Kaminski Mark S.
Wahl Richard L.
Chapman Lara E.
Coulter Pharmaceutical, Inc.
Wu Shean C.
LandOfFree
Radioimmunotherapy of lymphoma using anti-CD20 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Radioimmunotherapy of lymphoma using anti-CD20, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radioimmunotherapy of lymphoma using anti-CD20 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2322334