Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1978-12-11
1981-06-02
Hunt, Brooks H.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
424 12, 23230B, G01N 3348, G01T 100, A01K 4300
Patent
active
042711410
ABSTRACT:
The present invention provides an improved method for determining the thyroid function by means of an in vitro test using blood serum. Such a method involves an improvement of the procedure whereby (a) a patient's blood serum sample is mixed with a solution containing radioactive thyroxine and with a compound that liberates thyroxine from thyroxine-binding globulin; (b) the test mixture is buffered to achieve proper conditions for carrying out a thyroxine-binding immunoreaction; (c) an antiserum is added to provide antibodies which bind a portion of the thyroxine present by means of such a thyroxine-binding immunoreaction; (d) unbound thyroxine is thereafter separated from the antibody-bound thyroxine; and (e) the relative quantities of bound and unbound thyroxine are then determined by measurement of radioactivity.
In accordance with the present invention, such a procedure is improved by adding to the test mixture, after it has been appropriately buffered, a second additional sample of the patient's blood serum. This second sample of the patient's serum acts as a "correcting" or "normalizing" second binding agent, the addition of which improves the accuracy of thyroid function determination by means of the radioimmunoassay procedure.
REFERENCES:
patent: 3666854 (1972-05-01), Eisentraut
patent: 3911096 (1975-11-01), Chopra
patent: 4066410 (1978-01-01), Eisentraut
Byk-Mallinckrodt CIL B.V.
Hunt Brooks H.
Nucker Christine M.
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