Radioimmunoconjugates for targeted alpha therapy

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C424S178100

Reexamination Certificate

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07632927

ABSTRACT:
A radioimmunoconjugate for targeted alpha therapy comprises an alpha-emitter (e.g. Bi-213) linked to the monoclonal antibody C595. This radioimmunoconjugate is widely applicable in cancer therapy and is particularly efficient for treatment of pancreatic and prostate cancer, as well as for breast and ovarian cancer.

REFERENCES:
patent: WO 02/22685 (2002-03-01), None
Allen et al. (Crit. Rev. Oncol. Hematol. vol. 39(1-2), pp. 139-146), 2001).
Denton et al. (Br. J. Cancer, vol. 76(5), pp. 614-621, 1997).
Allen et al. (Crit. Rev. Oncol. Hematol. vol. 39(1-2), pp. 139-146), 2001) Abstract only.
Denton et al. (Br. J. Cancer, vol. 76(5), pp. 614-621, 1997) Abstract only.
Murray et al. (J of Nuclear Medicine, vol. 42, pp. 726-732, 2001).
Allen et al. (Critical Reviews in Onc./Hematology, vol. 39, pp. 139-146, 2001).
Perkins Alan et al; “Antibody conjugate radioimmunotherapy of superficial bladder cancer.”; Brazilian Archives of Biology and Technology; vol. 45, No. Special Issue, Sep. 2002, pp. 87-89, XP001204515; ISSN: 1516-8913.
Lo Benny: “Biotherapy” European Journal of Cancer, Pergamon Press, Oxford, GB, vol. 37, Oct. 2001, p. 228, XP004359247; ISSN: 0959-8049.
Seyed K I: “Advancements in cancer therapy with alpha-emitters: a review” International Journal of Radiation: Oncology Biology Physics, Pergamon Press, US, vol. 51, No. 1, Sep. 1, 2001, pp. 271-278, XP002206123; ISSN: 0360-3016.

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