Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1977-03-04
1978-08-22
Schafer, Richard E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 232306, 424 12, G01N 3316, A61K 4300, B01J 122
Patent
active
041089758
ABSTRACT:
An improved radioimmunoassey procedure involves the use of an improved reusable immunoadsorbent through which a sample of an antigen and radioactive labelled antigen is flowed to form a bound and unbound fraction. The bound fraction is releasably coupled to the immunoadsorbent which includes a solid particulate substrate to which antibodies, specific to the antigen, are covalently bonded by reaction between the carboxyl or amine group of the antibody and a group such as an acyl azide, carbonate, thiocarbonate, polythiol, isocyanate, epoxide and chlorothioformate group, for example, reacted on the substrate. The substrate includes a porous refractory material having at least one polymeric material bonded thereto as a barrier and to which is linked one of the above groups for reaction with the carboxyl or amine group of the antibody. The antigen bound to the immunoadsorbent is stoichiometrically released by an eluting solvent and the immunoadsorbent is reused. Concentration of the antigen is determined with reference to one of the bound or unbound fractions, or both.
REFERENCES:
patent: 3505785 (1970-04-01), Kirkland
patent: 3788948 (1974-01-01), Kagedal et al.
patent: 3796634 (1974-03-01), Haynes et al.
patent: 3896217 (1975-07-01), Johnson
patent: 3979184 (1976-09-01), Giaever
patent: 3979509 (1976-09-01), Giaever
Becton Dickinson and Company
Martella Mario A.
Nucker Christine M.
Schafer Richard E.
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