Radioimmunoassay for thyroid-stimulating hormone (TSH)

Details Radioimmunoassay for thyroid-stimulating hormone (TSH) Radioimmunoassay for thyroid-stimulating hormone (TSH)

1976-11-11

1978-05-09

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 232306, 424 12, A61K 4300, G01N 3316

Patent

active

040887464

ABSTRACT:
This invention provides a method for the radioimmunoassay of thyroid-stimulating hormone which utilizes a rapid and convenient version of a double antibody procedure. Highly purified second antibody is bound, by means of covalent bonds, to hydrolyzed polyacrylamide particles to produce a two-phase system. The solid phase comprises immobilized second antibody bound to the reaction product of labeled and unlabeled thyroid-stimulating hormone with the first antibody (first antibody-antigen complex) and the liquid phase comprises free (unbound) labeled and unlabeled thyroid-stimulating hormone. The two phases are separated and the radioactivity of either phase is measured.

REFERENCES:
patent: 3853987 (1974-12-01), Dreyer
patent: 4021534 (1977-05-01), Lafontaine
Koninckx et al, Acta Endocrinologica, vol. 81, No. 1, Jan., 1976, pp. 43-53.
Sluiter et al, Clinica Chimica Acta, vol. 42, Nov., 1972, pp. 255-262.

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