Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1978-08-10
1986-03-25
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
436500, 436539, 436540, 436541, 436542, 436804, 436817, 436825, 436826, 23230B, 232303, G01N 3356, G01N 3356, G01N 3360, G01T 100
Patent
active
RE0320986
ABSTRACT:
This invention relates to a highly accurate, rapid and simple estimation of thyroxine (T.sub.4) directly from blood serum and also relates to the accurate measurement of triiodo-L-thyronine (T.sub.3) directly from blood serum. More specifically, the invention relates to a rapid, specific and reliable radioimmunoassay (RIA) technique for measurement of both T.sub.4 and T.sub.3 in unextracted serum. The method requires very small amounts of serum, e.g., 25 microliters (.mu.l) to measure T.sub.4 concentration in nearly all specimens representing clinical states of eu-, hypo- and hyperthyroidism, and 250 .mu.l to measure T.sub.3 concentrations in specimens representing most clinical states.
REFERENCES:
patent: 3659104 (1972-04-01), Gross et al.
patent: 3710117 (1973-01-01), Gross et al.
patent: 3711247 (1973-01-01), Adams
patent: 3714344 (1973-01-01), Brown
patent: 3745211 (1973-07-01), Brown et al.
patent: 3749556 (1973-07-01), Barak et al.
patent: 3928553 (1975-12-01), Hollander
Chopra, Clin. Res. 19(1):125(1971).
Lieblich and Utiger, J. Clin. Invest. 50:60a(1971).
Mitsuma et al., J. Clin. Endocrinol. Metab. 33:364-367(1971).
Chopra et al., J. Clin. Invest. 50:2033-2041(1971).
Larsen, Metab. 20:976-980(1971).
Mitsuma et al., J. Clin. Invest. 50:2679-2688(1971).
Liebich and Utiger, J. Clin, Invest. 51:157-166(1972).
Green et al., Science 175:1378-1380(1972).
Chopra et al., J. Lab. Clin. Med. 80:729-739(1972).
Weber, G. (1952) Biochem. J., 51, 145 and 51, 155.
Laurence, D. J. R. (1952) Biochem. J., 51, 168.
Wolff, J. et al., (1961), J. Clinical Investigation, 40, 1373.
Osorio, C. (1962), J. Physiol., 163, 151.
Ingbar, S. H. (1963), J. Clinical Investigation, 42, 143.
Stryer, L. (1965), J. of Molecular Biology, 13, 482.
Gally, J. A. et al. (1965), Biochim. Biophys. Acta, 94, 175.
McClure, W. O. et al. (1966), Biochemistry, vol. 5, No. 6, 1908.
McClure, W. O. et al. (1967), Biochemistry, vol. 6, No. 2, 559.
Edelman, G. M. et al. (1968), Accounts Chemical Research, 1, 65.
Nucker Christine M.
Research and Education Institute, Inc.
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