Radioimmunoassay for determining the digoxin content of a sample

Details Radioimmunoassay for determining the digoxin content of a sample Radioimmunoassay for determining the digoxin content of a sample

1974-09-11

1976-09-21

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

23230B, 26023957, 424 8, 424 12, G01N 3300, G21H 502, C07J 1900

Patent

active

039819825

ABSTRACT:
A competitive radioimmunoassay for the measurement of digoxin in a serum sample in which the non-radioactive digoxin competes with a constant amount of a radioactively labeled digoxin tyramine analog comprising 3-O-(4-Hydroxyphenethylcarbamoyl) digoxigenin for binding cites on a limited amount of digoxin antibody. The percentage of the radioactively labeled digoxin which is bound to the antibody is inversely proportional to the concentration of digoxin in the serum sample. The concentration of digoxin in the serum is determined by the comparison with standards containing measured amounts of unlabeled digoxin.

REFERENCES:
Evered et al., Nuclear Science Abstracts, vol. 25, No. 2, Jan. 31, 1971, p. 245, Item No. 2522.
Johnston et al., Nuclear Science Abstracts, vol. 26, No. 15, Aug. 15, 1972, p. 3538, Item No. 36471.
Falch, Nuclear Science Abstracts, vol. 29, No. 8, Apr. 30, 1974, p. 1805, Item No. 18679.

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