Radioidohippuric acid ester, a conjugate thereof, and methods of

Details Radioidohippuric acid ester, a conjugate thereof, and methods of Radioidohippuric acid ester, a conjugate thereof, and methods of

1988-04-13

1989-11-28

Maples, John S

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

548542, 530389, 530402, A61K 4902, A61K 39395, C07D20746

Patent

active

048836508

ABSTRACT:
The novel N-hydroxysuccinimide ester of iodohippuric acid (IH-OSU), capable of forming a stable conjugate with a protein. The iodohippuric acid is preferably orthoiodohippuric acid (OIH) and radiolabeled. A protein compound useful as a radiolable comprises a stable conjugate of a protein and the N-hydroxysuccinimide ester of radiolabeled iodohippuric acid.

REFERENCES:
patent: 3859429 (1975-01-01), Elias
patent: 4057618 (1977-11-01), Salmon et al.
Rohrbach, M.S. "[Glycine-1-.sup.14 C]Hippuryl-L-Histidyl-L-Leucine]" analytical Biochemistry, 84,272-276 (1978).

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