Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1995-06-06
1996-10-29
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
424 153, 424 169, 424 4, 530323, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530331, 530350, 5303881, 53038825, 530502, 536 266, A61K 4748, A61K 4300, A61K 4904, A61K 4902, A61K 39395
Patent
active
055694462
ABSTRACT:
Compounds, useful as radiolabeling reagents, including a trihalogenated phenyl ring and having the formula ##STR1## wherein X.sub.1, X.sub.2 and X.sub.3 are halogens, one of which may be a radiohalogen, are disclosed. The invention further includes radiohalogenated proteins as well as processes for preparing such reagents and radiohalogenated proteins.
REFERENCES:
patent: 2611786 (1952-09-01), Wallingford
patent: 3144479 (1964-08-01), Obendorf
patent: 3359278 (1967-12-01), Wallingford
patent: 3476802 (1969-11-01), Holtermann et al.
patent: 3637824 (1972-01-01), Holtermann et al.
patent: 3883578 (1975-05-01), Gries
patent: 4001298 (1977-01-01), Gries et al.
patent: 4001323 (1977-01-01), Felder et al.
patent: 4014986 (1977-03-01), Tilly et al.
patent: 4031088 (1977-06-01), Ackerman
patent: 4321368 (1982-03-01), Hoey
patent: 4735792 (1988-04-01), Srivastava
patent: 4883650 (1989-11-01), Bhargava et al.
patent: 4885153 (1989-12-01), Wilbur et al.
patent: 5047228 (1991-09-01), Gries et al.
patent: 5089249 (1992-02-01), Fritzberg et al.
Eary et al., Antibodies in Radiodiagnosis and Therapy (Ed. Zalutsky), Chapter 5, Radiochemistry of Halogenated Antibodies, pp. 83-102. (1985).
Keenan et al., Monoclonal Antibiodies in Nuclear Medicine, J. Nucl. Med., 26, pp. 531-537 (1985).
Fritzberg et al., Approaches to Radiolabeling of Antibodies for Diagnosis and Therapy of Cancer, Pharm. Res., vol. 5, No. 6, pp. 325-334 (1988).
Zalutsky et al., Radiohalogenation of a Monoclonal Antibody Using an N-Succinimidyl 3-(Tri-n-butylstannyl)benzoate Intermediate, Cancer Res., 48, pp. 1446-1450 (1988).
Wilbur et al., Development of a Stable Radioiodinating Reagent to Label Monoclonal Antibodies for Radiotherapy of Cancer, J. Nucl. Med., 30, pp. 216-226 (1989).
Srivastava et al., Radioiodinated Iodophenyl Maleimide: A Potential Radioimmunoconjugate with Low In Vivo Deiodination, NucCompact, 20, pp. 145-149 (1989).
Stanko et al., Copper Catalysis on Isotopic Exchange as a Novel Approach to Incorporating Iodine and Bromine into Benzene Derivatives, Int. J. Radiat. Appl. Instrum. Part A, 35, pp. 1129-1132 (1984).
Sinn et al., Electrophilic Radioiodine Exchange Labeling in Aqueous Solutions, Int. J. Radiat. Appl. Instrum. Part A, 38, pp. 921-925 (1987).
Wilber, D. S., Radiohalogenation of Proteins: An Overview of Radionuclides, Labeling Methods, and Reagents for Conjugate Labeling, Bioconj. Chem., 3, pp. 433-470 (1992).
Bolton et al., The Labelling of Proteins to High Specific Radioactivities by Conjugation to a .sup.125 I-Containing Acylating Agent. Application to Radioimmunoassay, Biochem. J., 133, pp. 529-539 (1973).
Ogan Marc
Tomasella Frank P.
Tu Jan-I
Bracco International B.V.
Higel Floyd D.
Hoare, Jr. George P.
Rhoads Donald L.
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