Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1988-05-23
1994-04-12
Kim, Kay K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530345, 5303911, 5303913, 530405, 530409, 530410, 424 9, 436545, 436547, 436548, C07K 1528, C07K 1702, A61K 4902
Patent
active
053027000
ABSTRACT:
Compounds of the formulae, ##STR1## are provided where L is a linking group of the formula, ##STR2## is --Sn(n--C.sub.4 H.sub.9).sub.3 or --Sn(CH.sub.3).sub.3, HgCl or --N.sub.2.sup.+ ; R is hydrogen, methyl, mono-, di- or oligosaccharide; and R' is methyl. The compounds are site-specifically halogenated or radiohalogenated at the A group and coupled with macromolecules such as monoclonal antibodies, peptides or other proteins.
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Abstract preparation for The Society of Nuclear Medicine 40th Annual Meeting, Toronto Convention Center Jun. 8-Jun. 11, 1993 by Garg et al.
Manuscript entitled "N-succinimidyl-4-Methyl-3-(Tri-n-Butylstannyl)benzoate:Synthesis and Potential Utility for radioiodination of Monoclonal Antibodies" by Garg et al.
Garg et al., "Labeling Proteins Using Aryl Iodide Acylation Agents: Influence of Meta vs. Para Substitution on In Vivo Stability," Nucl. Med. Biol. vol. 16, No. 7, pp. 669-673, 1989.
Wilbur, et al., "Radioiodinated Iodobenzoyl Conjugates of a Monoclonal Antibody Fab Fragment. In Vivo Comparisons with Chloramine-T-Labeled Fab," Bioconjugate Chem. 1991, 2, 111-116.
Garg et al., "N-Succinimidyl 5-(Trialkylstannyl)-3-Pyridine Carboxylates: A New Class of Reagent for Protein Radioiodination", Bioconjugate Chem., 1991, 2, 50-55.
Narula Acharan S.
Zalutsky Michael R.
Duke University
Kim Kay K.
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