Radiohalogenated compounds for site specific labeling

Details Radiohalogenated compounds for site specific labeling Radiohalogenated compounds for site specific labeling

1988-06-07

1990-10-30

Maples, John S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564390, 424 11, 424 8591, 530391, 530405, C07C10910, A61K 4902, A61K 39395

Patent

active

049669990

ABSTRACT:
Radiohalogenated compounds which are useful as intermediates for preparing radiohalogenated antibody conjugates in which the radiohalogenated compound is site specifically attached to an oxidized carbohydrate moiety of an antibody or antibody fragment are disclosed. Methods for making the compounds and the antibody conjugates as well as methods of use of the same are also disclosed In particular, phenolic hydrazide and phenolic amine compounds are disclosed.

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Gersehngorn et al., in The Throid Gland: 81-121 (M. De Visscher ed. 1980).
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