Radiohalogenated benzazepine derivatives and method of imaging d

Details Radiohalogenated benzazepine derivatives and method of imaging d Radiohalogenated benzazepine derivatives and method of imaging d

1991-01-04

1992-07-14

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

540594, A61K 4902, C07D22316

Patent

active

051301172

ABSTRACT:
Novel CNS dopamine D-1 receptors, such as the compound (.+-.)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-(4'-[.sup.125 I]iodophenyl)-1H-3-benzazepine-7-ol, are disclosed. These compounds are useful as imaging agents for D-1 receptors in the human brain and exhibit good brain retention and in vivo stability.

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