Radiohalogenated benzamide derivatives and their use in...

Details Radiohalogenated benzamide derivatives and their use in... Radiohalogenated benzamide derivatives and their use in...

2005-03-10

2008-09-23

Jones, D. L (Department: 1618)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S001110, C424S001650, C424S001810, C424S001850, C424S009100

Reexamination Certificate

active

07427390

ABSTRACT:
This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with respect to tumor concentration and retardation, liver concentration and blood accumulation. The radiation-therapy doses to be achieved in the tumor, compared to healthy body tissue, are advantageous for the compounds according to the invention.

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patent: 7002022 (2006-02-01), Altmann et al.
patent: 7012081 (2006-03-01), Krueger et al.
patent: 7081468 (2006-07-01), Krueger et al.
patent: 7122547 (2006-10-01), Huth et al.
Radioiodinated N-(2-Diethylaminoethyl)benzamide Derivatives with High Melanoma Uptake: Structure-Affinity Relationships, Metabolic Fate, and Intracellular Localization, Michael Elsunhut et al. pp. 3913-3922, J. Med. Chem., 2000.

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