Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1979-01-30
1981-06-23
Padgett, Benjamin R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
23230B, 424 1, 424 12, G01N 3348, G01T 100, G01N 3354
Patent
active
042751500
ABSTRACT:
Normetanephrine, an N-methylatable phenylethanolamine, is converted to its N-methylated, tritiated derivative, metanephrine, utilizing phenylethanolamine-N-methyltransferase as enzyme and tritiated S-adenosyl-L-methionine as methyl donor. The formed tritiated derivative is selectively extracted in organic solvents and separated from other N-methylatable phenylethanolamines by thin layer chromatography. This assay could be used for measurement of normetanephrine in biological systems of patients with hypertension for detection of pheochromocytoma.
REFERENCES:
patent: 4041076 (1977-08-01), Avenia et al.
patent: 4108973 (1978-08-01), Avenia et al.
Haefliger William W.
Nucker Christine M.
Padgett Benjamin R.
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