Radioassay of folates

Details Radioassay of folates Radioassay of folates

1974-12-12

1976-10-26

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

23230B, A61K 4300, G21H 502, G01T 116

Patent

active

039884317

ABSTRACT:
In the radioassay of folates, the standard is prepared by using folic acid (pteroyl glutamic acid; PGA) as the standard folate at a pH of 9.2 to 9.4. At such pH values, folic acid and 5-methyltetrahydrofolic acid (the predominant folate in human serum) have essentially identical reactivity towards folate binders, whereby folic acid can replace unstable 5-methyltetrahydrofolic acid standard for such assays.

REFERENCES:
shaw et al., Chemical Abstracts, vol. 81, No. 13, Sept. 30, 1974, p. 182, Abstract No. 74448w.
Tajuddin et al., Chemical Abstracts, vol. 78, No. 17, Apr. 30, 1973, p. 207, Abstract No. 107854u.
Waxman et al., Chemical Abstracts, vol. 75, No. 16, Oct. 18, 1971, p. 80, Abstract No. 105931f.
DaCosta et al., Chemical Abstracts, vol. 75, No. 19, Nov. 8, 1971, p. 80, Abstract No. 116555n.
Rothenberg et al., Chemical Abstracts, vol. 71, No. 19, Nov. 10, 1969, p. 204, Abstract No. 89684n.

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