Radioactively labelled amino acid analogues, their...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent

Reexamination Certificate

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C424S009440, C424S009450, C514S345000, C514S358000, C546S290000, C546S300000, C546S329000, C546S346000

Reexamination Certificate

active

10523184

ABSTRACT:
The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula (I) wherein: R is (C1–C6) alkyl optionally substituted with thioether or ether oxygen atom when n=0, or a substituted aromatic or heteraromatic ring when n=1–6; and m=0 or 1; and X is a halogen atom. The invention further relates to precursor compounds for these analogues, to a method of preparing these analogues, to a pharmaceutical composition comprising these analogues and to the use of these analogues and compositions in the diagnosis of cancer

REFERENCES:
patent: 0 451 422 (1991-10-01), None
patent: 1220591 (1971-01-01), None
patent: 2020275 (1979-11-01), None
patent: WO 03/099746 (2003-12-01), None
Tetrahedron, Sheffer-Dee-Noor et al. 1994, 50(23), 7009-18.
Deehan, B et.al. “Uptake and Distribution of L-3-I-125 Lodo-alpha-methyl tyrosine in exp. rat . . . ” Euro.J.of Nuc. Med., Feb. 1993, p. 101-106,vol. 20, No. 2, Berlin, DE.
Wester H.J. et.al. “Synth. and Radi. of O-(′18F!fluorethyl)-L-tyrosine for tum. imag.”, J. of Nuc. Med.: Off. Publ., Soc. of Nuc.Med.,Jan. 1999,pp. 205-212, vol. 40,No. 1.
Ishiwata K. et.al.:“Synth. and Rad. Dos. of 4-Borono-2-(18F)Fluoro . . . ”, Intl. Jnl. of Rad., Jun. 25, 1990, pp. 325-328, vol. 42, No. 2, Pergamon PressLTD, GB.
Kawai K et. al.“Monoiodo-D-Tyrosine, an artif. Amino Acid . . . ”, Nuc. Med. and Bio., 1990, pp. 369-376, vol. 17, No. 4, Pergamon, Oxford, GB.
Bergstrom, et.al.“PET study of methionine accum. in glioma . . . ”, Jnl of Comp. Assist. Tomagraphy, 1987,pp. 208-213, vol. 11, No. 2,Raven Press, NY.
Coenen, et.al.“Cerebral metabolism of L-2-18F- . . . ”, J. Nucl. Med., Aug. 1989, pp. 1367-1372, vol. 30,No. 8.
Biersack, et. al.“Imaging of brain tumors with L-3-[123I]-iodo . . . ”, J. Nucl. Med., 1989, pp. 110-112, vol. 30.
Jager, P.L.et.al.,“Uptake mechanism of L-3-[125I]iodo-alpha-methyl- . . . ”Nuc. Med. Comm., 2001,pp. 87-96,vol. 22, No. 1, Lippincott Williams & Wilkins.
Lahoutte, et.al.“In vitro charac. of the influx of 3-[125I]iodo- . . . ”, Nuc. Med. of Bio., 2001,pp. 129-134, vol. 28,Elsevier Science Inc.
Heiss, et.al.“Invest. of transport mech. and uptake kinetics of O-2-[18f]fluoroethyl)-L- . . . ”, J. Nuc. Med., 1999,pp. 1367-1373, vol. 40.
Vekeman, et.al.,“L-[2-radioiodo]Tyrosine, a new potential protein synthesis . . . ”,Eur. J. Nuc. Med., 1999, pp. 971, vol. 26, No. 9.
Mertens, et.al.“Uptake study of L-2-I251-o-Tyrosine, . . . ”Eur. J. Nuc. Med.,2000, p. 1063, vol. 27.
Mertens, et.al.“New approach of cell uptake kinetics of L-2-123I-Tyr . . . ”, Eur. J. Nuc. Med. Mol. Imag., 2002, p. S377-P722, vol. 29.
Samnick, et.al.“Initial evaluation on the feasibility of SPECT with p-iodo-Lphenylalanine . . . ”, Nuc. Med. Com., 2002, pp. 121-130, vol. 23, No. 2, Lippincott Williams & Wilkins.
Rau, et.al.“O-(2-[(18)F]Fluoroethyl)-L-tyrosine (FET):a tracer for differentiation . . . ”, Eur. J. Nuc. Med. Mol. Imag., 2002, pp. 1039-1046, vol. 29, No. 8, Springer-Verlag.
Wester, et.al.“Synthesis and Radiopharm.of 0-(2-[18F]fluoroethyl)-L . . . ”, J. Nucl. Med., 1999, pp. 205-212, vol. 40.
Mertens, et.al.“Synthesis, radiosynthesis and in vitro charac . . . ”, Nuc. Med. Bio., 2004, pp. 739-746, vol. 31, Elsevier Inc.
Mertens,et.al.“L-[2-Radioiodo]-Tyrosine a potential tumour tracer for SPECT . . . ”,J. of Label.Comp. and Radiopharm.,May 2001,pp. S860-S862,vol. 44(Suppl. 1).
Hamacher, et.al.“Efficient rountine production of the 18F-labelled . . . ”, Applied Rad. and Isotopes, 2002, pp. 853-856, vol. 40(issue 6), Elsevier Science, Ltd.
Hamacher, et.al.“Convenient synth. of n.c.a. O-(2-[18F]Fluoroethyl)- . . . ”, J. Labelled Cpd. Radiopharm., 2001, p. S855, vol. 44.
Lahoutte, et.al.“Comparative Biodistrib. of Iodinated Amino Acids in Rats . . . ”,Biodistrib.of Iodinated Aminos Acids, 2003, pp. 1489-1494, vol. 44, No. 9.

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