Radioactively labeled peptides comprising a single thiol moiety

Details Radioactively labeled peptides comprising a single thiol moiety Radioactively labeled peptides comprising a single thiol moiety

1998-09-28

1999-11-30

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 165, 530300, 530326, 534 10, 534 14, A61K 5100, A61M 3614

Patent

active

059937750

ABSTRACT:
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind technetium-99m, rhenium-186, or rhenium-188 and which can be targeted to specific sites within a mammalian body.

REFERENCES:
patent: 4986979 (1991-01-01), Morgan
patent: 5443815 (1995-08-01), Dean
patent: 5561220 (1996-10-01), Dean
patent: 5670133 (1997-09-01), Zamora
patent: 5736122 (1998-04-01), Dean et al.
patent: 5807537 (1998-09-01), Dean
patent: 5814297 (1998-09-01), Dean et al.
patent: 5866097 (1999-02-01), Dean et al.
patent: 5879658 (1999-03-01), Dean et al.
Deutsch, et al, (1986) "The Chemistry of Rhenium and Technetium as Related to the Use of Isotopes of these Elements in Therapeutic and Diagnostic Nuclear Medicine," Nucl. Med. Biol., 13, 465-477.

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