Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2008-07-08
2008-07-08
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001110, C424S001370, C424S001770
Reexamination Certificate
active
10533988
ABSTRACT:
The present invention provides radioactive metal heterocomplexes of formula (I): [(Me═N—R)L1L2]+Z (I), wherein Me, R, L1L2and Z−have the meanings indicated in the description. The complexes include a trivalent radioactive metal-imido group, typically a technetium- or rhenium-imido group, strongly stabilized by the presence of an ancillary tridentate hetero-diphosphine ligand L1, which allows the formation of substitution-inert [(Me═N—R)L1] moieties. Such moieties are fixed in an intermediate [(Me═N—R)Y2L1)]+compound which contains two labile, cispositioned, Y ligands, where Y is preferably an halide group. The latter are easily replaced by a bidentate ligand L2to give the final [(Me═N—R)L1L2]+Z−heterocomplexes. The complexes of the invention are useful for the preparation of radiopharmaceuticals: in fact, a bioactive fragment which confers biological target-seeking properties can be introduced either on the L2framework or the imido R group.
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Arterburn et al. “Functionalized organomidorhenium(V) complexes as potential radiopharmaceuticals: syntheses of glycine derivatives and the structure determination of a rhenium analogue of chlorambucil”Angewandte Chemie. International Edition, vol. 35, No. 23/24, Jan. 3, 1997. (Abstract), incorrect year, no page numbers listed.
Arterburn et al. “Functionalized organomidorhenium(V) complexes as potential radiopharmaceuticals: syntheses of glycine derivatives and the structure determination of a rhenium analogue of chlorambucil” Angewandte Chemie. International Edition, vol. 35, No. 23/24, 1996, pp. 2877-2879.
Bolzati Cristina
Porchia Marina
Refosco Fiorenzo
Tisato Francesco
Bracco Imaging S.p.A.
Hartley Michael G.
Kramer Levin Naftalis & Frankel LLP
Perreira Melissa
LandOfFree
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