Radioactive rhenium ligated to 2-hydroxy isobutyric acid and met

Details Radioactive rhenium ligated to 2-hydroxy isobutyric acid and met Radioactive rhenium ligated to 2-hydroxy isobutyric acid and met

1989-04-04

1990-05-15

Maples, John S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

556 49, 556 50, 424 11, C07F 1300, C01G 4700

Patent

active

049259253

ABSTRACT:
A composition of matter having the following general formula ##STR1## wherein L represents 2-hydroxy isobutyric acid. This composition of matter is useful in improving the reaction efficiency or yield when bonding rhenium to a chelating ligand preferably a polydentate sulfur, selenium, phosphorous or nitrogen ligand. This provides a method to bond radioactive rhenium to various chelating ligands for a radiopharmaceutical. Further, this also provides a method to bond a radioactive rhenium to a protein such as a monoclonal antibody. This in turn provides a method to provide beta emitting radiation to cancer cells.

REFERENCES:
patent: 4452774 (1984-06-01), Jones et al.
patent: 4707544 (1987-11-01), Jones et al.
patent: 4778672 (1988-10-01), Deutsch et al.

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