Radioactive rhenium complexed to 2-hydroxy isobutyric acid

Details Radioactive rhenium complexed to 2-hydroxy isobutyric acid Radioactive rhenium complexed to 2-hydroxy isobutyric acid

1988-06-15

1989-06-13

Maples, John S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

424 11, 556 49, 556 50, C07F 1300, C01G 4700

Patent

active

048394670

ABSTRACT:
A composition of matter having the following general formula ##STR1## wherein L represents 2-hydroxy isobutyric acid. This composition of matter is useful in improving the reaction efficiency or yield when bonding rhenium to a chelating ligand preferably a polydentate sulfur, selenium, phosphorous or nitrogen ligand. This provides a method to bond radioactive rhenium to various chelating ligands for a radiopharmaceutical. Further, this also provides a method to bond a radioactive rhenium to a protein such as a monoclonal antibody. This in turn provides a method to provide beta emitting radiation to cancer cells.

REFERENCES:
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patent: 4633001 (1986-12-01), Cells
patent: 4652440 (1987-03-01), Paik et al.
patent: 4778672 (1988-10-01), Deutsch et al.
M. R. Zalutsky et al, Nucl. Med. Biol. vol. 15, No. 2, pp. 151-156, 1988.
R. W. Kozak, Tibtech, Oct. 1986, pp. 259-264.
Sixth Int'l. Symposium on Radiopharmaceutical Chemistry, Boston 6-29 thru 7-3-1986, pp. 269-270, S. Kasina et al.
Thun et al., "Stability Constants of Some Bivalent Metal Complexes," Anal. Chim. Acta. 37(3), 332-8 (1967) [CA: 66: 119436z].

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