Radioactive phosphorus labeled proteins for targeted radiotherap

Details Radioactive phosphorus labeled proteins for targeted radiotherap Radioactive phosphorus labeled proteins for targeted radiotherap

1997-11-26

1999-11-02

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 153, 424 173, 424 177, 4241791, 5303913, 5303915, 530404, 530405, 530408, 530409, A61K 5100, A61K 39395, C07K 1600

Patent

active

059764929

ABSTRACT:
.sup.32 P- and .sup.33 P-labeled proteins which are useful for radiotherapy are prepared by stably linking .sup.32 P- or .sup.33 P-containing molecules to targeting proteins in such a way that the targeting protein retains the ability to bind to a cellular target. Methods for preparing the labeled proteins and their use in methods of radiotherapy are described.

REFERENCES:
Schmidt et al. FEBS Lett. 194:305 (1986).
Hwang et al. Biochim. Biophys. Acta 882:331 (1986).
De Boer et al. Clin. Exp. Immunol. 3:865 (1968).
Clertant et al. J. Biol. Chem. 257:6300 (1982).
Foxwell et al. Brit. J. Cancer 57:489 (1988).
Craeighton et al. "The development of .sup.32 P technology for radioimmunotherapy" in Monoclonal Antibodies 2: Applications in Clinical Oncology, A.A. Epenetos, ed., Chapman and Hall, (1993) pp. 103-109.
Cook "Medicinal Chemistry of Antisense Oligonucleotides Future Opportunities," Anti-Cancer Drug Design 6: 585-607 (1991).

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