Radioactive peptides

Details Radioactive peptides Radioactive peptides

1993-07-21

1997-04-15

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

530500, 530322, 530311, 424 173, 424 93, 424 935, 424 94, 424 943, 424 96, A61K 3831, A61K 3800, A61K 5100

Patent

active

056206755

ABSTRACT:
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing label radiodiagnostic agents. Specifically, the invention relates to linear peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to linear peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention so specifically relates to liner peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provide.

REFERENCES:
patent: 4235886 (1980-11-01), Freidinger
patent: 4444690 (1984-04-01), Fritzberg
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4485101 (1984-11-01), Coy et al.
patent: 4608251 (1986-08-01), Mia
patent: 4611054 (1986-09-01), Freidinger
patent: 4612366 (1986-09-01), Nutt
patent: 4853371 (1989-08-01), Coy et al.
patent: 4871717 (1989-10-01), Coy et al.
patent: 4904642 (1990-02-01), Coy et al.
patent: 5073541 (1991-12-01), Taylor et al.
patent: 5084442 (1992-01-01), Felix et al.
patent: 5196510 (1993-03-01), Rodwell et al.
patent: 5212072 (1993-05-01), Blalock et al.
patent: 5225180 (1993-07-01), Dean et al.
Reubi et al, Chem Abstracts, 103: 135620 (1985).
Bomanji et al., 1992, "A scintigraphic comparison of iodine-123-metaiodobenzylguanidine and an iodine-labeled somatostatin analog (Tyr-3-octreotide) in metastatic carcinoid tumors", J. Nucl. Med. 33: 1121-1124.
Krenning et al., 1992, "Somatostatin receptor scintigraphy with indium-111-DTPA-D-Phe-1-octreotide in man: Metabolism, dosimetry and comparison with iodine-123-Tyr-3-octreotide", J. Nucl. Med. 33: 652-658.
Cox et al., 1991, "Technetium Labeled Somatostatin: A Potential Agent for In Vivo Tumour Localization", Abstract, 7th International Symposium on Radiopharmacology, p. 16.
Albert et al., 1991, "A Somatostatin Analogue to Image SS-Receptor-Positive Tumours: [.sup.111 In-DTPA-DPhe]1.sup.1 -Octreotide (SDZ 215-811)", Abstract LM10, 12th American Peptide Symposium: 1991.
Faglia et al., 1991, "In vivo detection of somatostatin receptors in patients with functionless pituitary adenomas by means of a radioiodinated analog of somatostatin ([.sup.123 I])SDZ 204-090)", J. Clin. Endocrinol. Metab. 73: 850-856.
Larson, 1991, "Receptors on Tumors Studied with Radionuclide Scintigraphy", J. Nucl. Med. 32: 1189-1191.

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