Radioactive mixture and manufacturing method thereof

Details Radioactive mixture and manufacturing method thereof Radioactive mixture and manufacturing method thereof

2009-01-16

2011-11-01

Jones, D L (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

C424S001110, C424S001650, C534S014000

Reexamination Certificate

active

08048405

ABSTRACT:
A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO4−/or ReO4−, and then dissolved in Lipiodol. Moreover, the99mTc/or188Re of the TcO4−/or ReO4−avoids bone marrow injuries caused by free90Y. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented.188Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.

REFERENCES:
patent: 7067508 (2006-06-01), Jeong et al.

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