Radioactive metals complexed with phosphonate derivatives of dic

Details Radioactive metals complexed with phosphonate derivatives of dic Radioactive metals complexed with phosphonate derivatives of dic

1983-06-20

1985-05-07

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

260429J, 2604292, 2604297, 2605025E, 562499, 424 9, A61K 4900, A61K 4300

Patent

active

045157677

ABSTRACT:
Complexes of radionuclides with a compound of the formula ##STR1## wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) phosphonic, sulfonic, methylenephosphonic, methylene-, ethylene- and propylene-sulfonic, carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts, thereof and wherein at least one A, B, X and Y is methylenephosphonic acid or a salt thereof. Tc-99m complexes have been found useful for imaging the skeletal structure of animals.

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patent: 4082840 (1978-04-01), Adler et al.
patent: 4387087 (1983-06-01), Deutsch et al.
Radiology, vol. 99, pp. 192-196, 1971.
Radiology, 136: 209-211, Jul. 1980.
Radiology, 136: pp. 747-751, Sep. 1980.
J. Nuc. Med. 21: pp. 767-770, 961-966, (1980).

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