Radioactive labeling of proteins with nucleosides or nucleotides

Details Radioactive labeling of proteins with nucleosides or nucleotides Radioactive labeling of proteins with nucleosides or nucleotides

1984-11-27

1987-09-08

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

422 61, 424 11, 435 6, 435 29, 435 34, 530380, 530389, 530395, 530406, 530410, 530411, A61K 4300, A61N 512

Patent

active

046925090

ABSTRACT:
A radioactively labeled protein comprising a protein, and a radioactive nucleoside or nucleotide, the protein being covalently linked to the nucleoside or nucleotide. Advantageously the linkage is through an NH.sub.2 group of the protein and through a carbonyl group of a ring-opened sugar moiety of the nucleoside or nucleotide. The protein can be insulin, an immunoglobulin or protein A. The radioactive moiety may be a P, C, S, H, I or Hg atom. The labels can be used to indicate the presence and amount of the protein in a biological assay.

REFERENCES:
patent: 4259232 (1981-03-01), Carrico et al.
patent: 4358535 (1982-11-01), Falkow et al.
patent: 4469796 (1984-09-01), Axen et al.
DNA Replication, Kornberg (1980), pp. 4-6.
Biochem. Soc. Trans., 12(2), 1984, 279-280, Woodhead et al.

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