Radioactive iodine (125I) labeling of latex particles

Details Radioactive iodine (125I) labeling of latex particles Radioactive iodine (125I) labeling of latex particles

1975-03-06

1977-03-01

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

2523011R, 526 21, A61K 4300

Patent

active

040102505

ABSTRACT:
The invention disclosed in this application is directed towards developing a radioiodination method which is applicable to the labeling of 2.02 micrometer (.mu.m) and 0.37 micrometer (.mu.m) diameter polyvinyltoluene latex particles that have been used as an immunoadsorbent. More particularly the overall method includes using an oxidation-reduction chemical reaction for tagging latex particles. Two methods are described. One, the hydrochloric acid method; and two, the nitric acid method.

REFERENCES:
patent: 3039977 (1962-06-01), Ingram
patent: 3853987 (1974-12-01), Dreyer
VAN Oss et al., "The Binding of Immune Globulins . . . Particles," Journal f the Reticuloendothelial Soc., vol. 3, pp. 29-40, (1966).
Keenan et al., General College Chemistry, Harper & Row, Pub., Inc., New York, 1957, p. 559.

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