Radioactive diagnostic agent and non-radioactive carrier therefo

Details Radioactive diagnostic agent and non-radioactive carrier therefo Radioactive diagnostic agent and non-radioactive carrier therefo

1981-11-25

1984-04-03

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, A61K 4300, A61K 4900

Patent

active

044407394

ABSTRACT:
A .sup.99m Tc-labeled radioactive diagnostic agent being useful for visualization and dynamic inspection of hepatobiliary ducts and having a high stability and no material toxicity, which comprises .sup.99m Tc in the form of pertechnetate and a non-radioactive carrier, the non-radioactive carrier comprising an N-pyridoxyl-.alpha.-amino acid of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each an atom or an atomic group present in the .alpha.-amino acid residue encompassed by the dotted line and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.10 alkyl group or a C.sub.1 -C.sub.10 alkyl group substituted with at least one hydrophilic group or its salt, and a reducing agent for pertechnetate.

REFERENCES:
patent: 3740418 (1973-06-01), Rajamani et al.
patent: 4215045 (1980-07-01), Knapp, Jr.
patent: 4256726 (1981-03-01), Kato
patent: 4298591 (1981-11-01), O'Brien, Jr. et al.
Chiotellis et al., Chem. Abstracts, vol. 87 (1977) #98177g.

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