Radioactive determination of serum thyroxine

Details Radioactive determination of serum thyroxine Radioactive determination of serum thyroxine

1973-05-29

1976-03-30

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 250303, G01N 3300, G01T 116

Patent

active

039475646

ABSTRACT:
A method for determining serum thyroxine (T-4) in which the T-4 is first separated from the serum by adsorption onto a montmorillonite clay and then competitively bound by exogenous thyroxine binding globulin in the presence of a known amount of radioactive T-4. The competitively bound serum T-4 and radioactive T-4 is separated from the unbound serum T-4 and radioactive T-4 by passage through an ion exchange resin column. The serum T-4 concentration is determined by measuring the amount of bound radioactive T-4 and referring to a standard curve.

REFERENCES:
patent: 3414383 (1968-12-01), Murphy
patent: 3451777 (1965-08-01), DiGiulio
patent: 3555001 (1971-01-01), Wallis et al.
patent: 3659104 (1972-04-01), Gross et al.
patent: 3666854 (1972-05-01), Eisentraut
patent: 3714344 (1973-01-01), Brown
patent: 3776698 (1973-12-01), Eisentraut

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