Radioactive compositions for the treatment of calcific tumors

Details Radioactive compositions for the treatment of calcific tumors Radioactive compositions for the treatment of calcific tumors

1987-03-03

1990-01-30

Locker, Howard J.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, A61K 4300, C07F 1100

Patent

active

048972541

ABSTRACT:
Certain particle-emitting radionuclides, e.g. Samarium-153, have been complexed with certain alkylenepolyaminocarboxylic acid chelants. Compositions containing these complexes have been found useful in the treatment of calcific tumors in animals. The stability constant, log K, of the useful complexes is from about 14 to about 17 and the molar ratio of chelant to radionuclide in the compositions is such that the chelant is present in an amount sufficient to inhibit uptake of the radionuclide by soft tissue.

REFERENCES:
patent: 3965254 (1976-06-01), Tofe et al.
patent: 4017596 (1977-04-01), Loberg et al.
patent: 4088747 (1978-05-01), Hunt et al.
patent: 4091088 (1978-05-01), Hunt et al.
patent: 4308249 (1981-12-01), Frank et al.
patent: 4352751 (1982-10-01), Wieder et al.
patent: 4399817 (1983-08-01), Benedict
patent: 4560548 (1985-12-01), Simon et al.
patent: 4606907 (1986-08-01), Simon et al.
patent: 4647447 (1987-03-01), Gries et al.
Journ. Nucl. Med., vol. 1 (1960) pp. 1-13.
Journ. Nucl. Med., vol. 10 (1969) pp. 49-51, O'Mara et al.
Int. J. Clin. Pharmacol., 9, 3 (1974) pp. 199-205.
Journal of Urology, vol. 116 (1976) pp. 764-768.
Seminars in Nucl. Med., vol. IX, No. 2, (Apr. 1979) pp. 114-120.
19th Int. Annual Meeting Soc. Nucl. Med. Europe, Bern Switzerland, 9-8/11-81.
Journ. Nucl. Med., vol. 24 (1983) p. P-125.
Journ. Nucl. Med., vol. 25 (1984) pp. 1356-1361.
Journ. Nucl. Med., vol. 25 (1984) p. P-129.
Int. J. Applied Rad. & Isotopes, Mathisu, L. et al., vol. 30, pp. 725-727 (1979).
Int. J. of Applied Radiation & Isotopes, vol. 14, pp. 129-135 (1963) Rosoff et al.
Technical Report from the Medical Dept., Brookhaven Nat. Lab. (BNL-24614).
Chemical Abstract 70:100130f.
Chemical Abstract 76:37422j.
Chemical Abstract 84:129901h.
Chemical Abstract 912:97498h.
Gilyazutdinou et al., CA82:108229p (1975).
Thakur et al., CA100:180971g (1984).

Affiliated with

Also associated with

Rating

Radioactive compositions for the treatment of calcific tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Radioactive compositions for the treatment of calcific tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radioactive compositions for the treatment of calcific tumors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1922708