Radioactive chitosan complex for radiation therapy

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Coated – impregnated – or colloidal particulate

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 133, 424 165, 424 173, 600 3, A61K 5112, A61K 5106, A61N 500

Patent

active

057629030

ABSTRACT:
The present invention relates to the radioactive chitosan complex formed by labelling a chitosan, a biocompatible and biodegradable natural polymer, with radionuclide, a radioactive chitosan macroaggregate formed by making chitosan complex into particles, and a kit for preparing radioactive chitosan complex, process for preparation thereof and the use thereof for an internal radiation therapeutic agent. The radioactive chitosan complex and its macroaggregate can be used as an internal radiation therapy for rheumatoid arthritis or cystic cancer such as liver cancer, brain cancer, breast cancer, ovary cancer and the like by administering them directly to the lesion.

REFERENCES:
patent: 4424346 (1984-01-01), Hall et al.
patent: 4946435 (1990-08-01), Suthanthiran et al.
patent: 5219749 (1993-06-01), Bouriotis et al.
patent: 5268129 (1993-12-01), Simon et al.
patent: 5271924 (1993-12-01), Hashiguchi et al.
patent: 5300280 (1994-04-01), DeRosch et al.
patent: 5342283 (1994-08-01), Good
patent: 5364613 (1994-11-01), Sieving et al.
patent: 5422116 (1995-06-01), Yen et al.
Andrews et al., "Hepatic Radioembolization with Yttrium-90 Containing Glass Microspheres: Preliminary Results and Clinical Follow-up", Journal of Nuclear Medecine 1994, vol. 35, pp. 1637-1646.
Mumper et al., "Neutron-Activated Holmium-166-Poly (L-Lactic Acid) Microspheres: A Potential Agent for the Internal Radiation Therapy of Hepatic Tumors", Journal of Nuclear Medicine 1991, vol. 32, pp. 2139-2143.
Will et al., "Comparison of Two Yttrium-90 Regimens in Inflammatory and Osteoarthropathics", Annals of the Rheumatic Diseases 1992, vol. 51, pp. 262-265.
Chinol et al., "Chemistry and Biological Behavior of Samarium-153 and Rhenium-186-Labeled Hydroxyapatite Particles: Potential Radiopharmaceuticals for Radiation Synovectomy", Journal of Nuclear Medicine, 1993, vol. 34, pp. 1536-1542.
Knorr, "Functional Properties of Chitin and Chitosan", Journal of Food Science 1982, vol. 47, pp. 593-595.
Hnatowich et al., "Dysprosium-165 Ferric Hydroxide Macroaggregates for Radiation Synovectomy", Journal of Nuclear Medecine 1977, vol. 19, No. 3, pp. 303-308.
Wang et al. "Preparation and Biodistribution of Yttrium-90 Lipiodolin Rats Following Hepatic Arterial Injection", European Journal of Nuclear Medicine, Mar. 1995, vol. 22, No. 3, pp. 233-236.
McLaren et al., "Dysprosium (.sup.165 Dy) Hydroxide Macroaggregates for Radiation Synovectomy-Animal Studies", European Journal of Nuclear Medicine 1990, vol. 16, pp. 627-632.
Clunie et al., "Samarium-153-Particulate Hydroxyapatite Radiation Synovectomy: Biodistribution Data for Chronic Knee Synovitis", Journal of Nuclear Medicine 1995, vol. 36, pp. 51-57.
Chemical Abstracts, vol. 123, No. 16, 16 Oct. 1995, Abstract No. 217120.
Chemical Abstracts, vol. 108, No. 1, 4 Jan. 1988, Abstract No. 1631.
Chemical Abstracts, vol. 124, Abstract No. 311363, Jan. 1996.
Patent Abstracts of Japan, vol. 13, No. 516 (C-656), 17 Nov. 1989.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Radioactive chitosan complex for radiation therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Radioactive chitosan complex for radiation therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radioactive chitosan complex for radiation therapy will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2195715

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.