Radioactive benzodiazepine derivatives

Details Radioactive benzodiazepine derivatives Radioactive benzodiazepine derivatives

1988-10-05

1989-12-05

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

540504, A61K 4902, C07D24324

Patent

active

048851523

ABSTRACT:
The present invention relates to a novel radioactive benzodiazepine derivative represented by the formula: ##STR1## wherein R is hydrogen or a lower alkyl; X* is radioactive iodine or bromine; Y is hydrogen or a halogen; and Z is a halogen or nitro group; and the salt thereof.
The compound of the present invention enables to non-invasively detect the presence of benzodiazepine receptors in human or animal brains, other organs or tissues. Additionally, it enables to dynamically trace the change in receptor concentration either. It is very useful as a radioactive diagnostic agent for nuclear medicine in vitro or in vivo or as a radio-pharmaceutical.

REFERENCES:
patent: 3906003 (1975-09-01), Akatsu et al.
patent: 3991048 (1976-11-01), Ishizumi et al.
patent: 4083948 (1978-04-01), Davis et al.
patent: 4280993 (1981-07-01), Braestrup et al.
patent: 4606908 (1986-08-01), Bassingthwaighte et al.
Van Dort et al., "Radioiodinated Benzodiazedines", J. Med. Chem., 31(11), 2081-6, [C.A. 109(21):190379v].
The Journal of Nuclear Medicine (Abstract Book), vol. 28, No. 4, Apr. 1987, pp. 726-727, abstract No. 719, New York, N.Y., U.S.; M. E. Vandort et al.: "Iodinated Peripheral Benzodiazepine Receptor-Binding Ligands".
J. Psychiat. Res., vol. 19, No. 4, 1985, pp. 609-622, Pergamon Press Ltd., GB; A. Persson et al.: "Imaging of (11C)-Labelled RO 15-1788 Binding to Benzodiazepine receptors in the Human Brain by Positron Emission Tomography".
Int. J. Appl. Radiat. Isot., 35, 973-976, (1984).
Neuroscience Letters, 48, 115-120, (1984).
J. Psychiatric Res., 19, 609-622, (1985).

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