Radio-iodine-labelled omega phenyl fatty acids

Details Radio-iodine-labelled omega phenyl fatty acids Radio-iodine-labelled omega phenyl fatty acids

1982-07-14

1984-09-25

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, A61K 4300, A61K 4900

Patent

active

044735448

ABSTRACT:
Radio-iodine-labelled omega-phenyl fatty acid of the formula: ##STR1## in which: X is an alkylene group having from 6 to 20 carbon atoms; R is hydrogen or an alkyl or alkoxy group having 1 or 2 carbon atoms; Y is hydrogen, an alkali metal ion, alkaline earth metal ion or ammonium ion; and I is a radioactive iodine-123 or iodine-131 isotope which may be in the ortho- or para-position of the benzene nucleus,
a process for the preparation of these radio-iodine-labelled phenyl fatty acids, and products containing them for scintigraphic examination of various organs of the body such as the heart and the liver.

REFERENCES:
patent: 2580459 (1952-01-01), Papa et al.
patent: 3061510 (1962-10-01), Numerof et al.
patent: 4202874 (1980-05-01), Akerkar
patent: 4219538 (1980-08-01), Sprinkle
patent: 4290965 (1981-09-01), Stocklin et al.
patent: 4323547 (1982-04-01), Knust et al.
Machulla et al., European Journal of Nuclear Medicine, 5, pp. 171-173 (1980).
Machulla et al., Journal of Nuclear Medicine, 19, No. 3, pp. 299-301 (1978).
Mattsson, International of Applied Radiation and Isotopes, May/Jun. 1976, pp. 319-323 (1978).
Wieland et al., J. Label. Comp. Radiopharmaceuticals, 16, 171 (1979).

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