Radio-immuno assay for hepatitis B virus PreS2 antibodies

Details Radio-immuno assay for hepatitis B virus PreS2 antibodies Radio-immuno assay for hepatitis B virus PreS2 antibodies

1989-08-03

1992-02-25

Ceperley, Mary E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

4352351, 435810, 435948, 436501, 436518, 436534, 436543, 436547, 436804, 436808, 436820, C12Q 170

Patent

active

050913000

ABSTRACT:
Anti-hepatitis B virus surface protein (anti-HBS) antibody is adsorbed onto the surface of a substratum. Hepatitis B virus PreS2+S (PreS2+S) protein is then adsorbed onto the same surface through the interaction of the anti-HBS antibody with the "S" portion of the PreS2+S protein. The coated surface is then incubated concomitantly with the test sample and a radiolabelled antibody specific for the "PreS2" portion of the PreS2+S protein.

REFERENCES:
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patent: 4963483 (1990-10-01), Ellis et al.
patent: 5028524 (1991-07-01), Fujisawa et al.
Hurni, W. M. et al., J. Med. Virol. (Submitted 1989).
Coursaget, P. et al., Vaccine 6, pp. 357-361 (1988).
Budkowska, A., et al., Journal of Immunological Methods, 102, pp. 85-92 (1987).
Neurath, A. R. et al., Vaccine, 4, pp. 35-37 (1986).
Neurath, A. R. et al., Journal of General Virology, 67, pp. 453-461 (1986).

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