Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-10-27
1999-11-02
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549268, 549270, A61K 31335, C07D31300
Patent
active
059771658
ABSTRACT:
The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R.sup.4 --O--N (wherein R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl); and R.sup.3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R.sup.3 are combined with each other to represent a single bond; Y represents R.sup.4B --O--N (wherein R.sup.4B has the same meaning as R.sup.4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects.
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Chemical Abstracts, vol. 127: 176300 (Abst. of Shibata et al, Jpn. Kokai Tokyo Koho JP 09202781 Aug. 5, 1997).
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Agatsuma Tsutomu
Akasaka Kazuhito
Akinaga Shiro
Gomi Katsushige
Mizukami Tamio
Dentz Bernard
Kyowa Hakko Kogyo Co. Ltd.
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