Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Reexamination Certificate
2007-07-24
2007-07-24
Navarro, Mark (Department: 1645)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
C424S093200, C424S093400
Reexamination Certificate
active
11330017
ABSTRACT:
The invention can be summarized as follows. According to the present invention there is provided an attenuated, tumour-targeting bacterium comprising a heterologous nucleotide sequence encoding a protein permitting the accumulation of a radionuclide within the bacterium. The heterologous nucleotide sequence may encode a sodium iodide symporter protein. The invention also relates to the use of such bacteria and methods of treating diseases using the bacteria of the present invention.
REFERENCES:
patent: 5816259 (1998-10-01), Rose
patent: 6015376 (2000-01-01), Ain et al.
patent: 6080849 (2000-06-01), Bermudes et al.
patent: 6190657 (2001-02-01), Pawelek et al.
patent: 6391579 (2002-05-01), Carrasco et al.
patent: 6586411 (2003-07-01), Russell et al.
patent: 6685935 (2004-02-01), Pawelek et al.
patent: 6803199 (2004-10-01), Carrasco et al.
patent: 7015027 (2006-03-01), Redshaw
patent: WO-96/40238 (1996-12-01), None
patent: WO-97/18837 (1997-05-01), None
patent: WO-01/13106 (2001-02-01), None
Adler, J. , “A Method For Measuring Chemotaxis and Use of the Method to Determine Optimum Conditions for Chemotaxis byEscherichia coli”, Journal of General Microbiology 74, (1972),77-91.
Barrows, Louis R., “Evidence for the CloningofDeinococcus radioduransDNA Fragments that RenderEscherichia coliRadiation Resistant”,Radiation Research 120, (1989),pp. 537-544.
Battista, Joihn R., et al., “Radiation Resistance: The Fragments that Remain”,Current Biology, 10(5), (Mar. 9, 2000),R204-R205.
Battista, John R., et al., “Why isDeinococcus radioduransSo Resistant to Ionizing Radiation”,Trends in Microbiology, 7(9), (Sep. 1999),362-365.
Bauche, Cecile , et al., “Repair of Oxidized Bases in the Extremely Radiation-Resistant BacteriumDeinococcus radiodurans”, Journal of Bactriology, 181(1), (Jan. 1999),262-269.
Benvenga, S , et al., “Homologies of the Thyroid Sodium-Iodide Symporter With Bacterial and Viral Proteins”,Journal Endocrinol Invest, 22(7), (Jul.-Aug. 1999),535-540.
Bermudes, David , et al., “Tumor-TargetedSalmonella”, Cancer Gene Therapy, (2000),pp. 57-63.
Boland, Anne , et al., “Adenovirus-Mediated Transfer of the Thyroid Sodium/Iodide Symporter Gene Into Tumors for a Targeted Radiotherapy”,Cancer Research 60., (Jul. 2000),pp. 3484-3492.
Braverman, Lewis E., et al., “The Thyroid”,Werner&Ingbar, 7th Ed, (1996),pp. 922-945.
Brown, J. M., “Hypoxic Cell Radiosensitizers: Where Nex?”,Journal of Radiation Oncology—vol. 16, (1988),pp. 987-993.
Carlin, Sean , et al., “Experimental Targeted Radioiodide Therapy Following Transfection of the Sodium Iodide Symporter Gene: Effect on Clonogenicity in Both Two-And-Three-Dimensional Models”,Cancer Gene Therapy, 7(12), (2000),1529-1536.
Clairmont, C. , et al., “Biodistribution and Genetic Stability of the Novel Antitumor Agent VNP20009, A Genetically Modified Strain ofSalmonella typhimurium”, The Journal of Infectious Diseases, (2000),pp. 1996-2002.
Dadachova, E. , et al., “Rhenium-188 As An Alternative to Iodine-131 for Treatment of Breast Tumors Expressing the Sodium/Iodide Symporter (NIS)”,Nuclear Medicine and Biology 29., (2002),pp. 13-18.
Dai, GE , et al., “Cloning and Characterization of The Thyroid Iodide Transporter”,Nature, vol. 379., (1996),pp. 458-460.
Dalrymple, G. V., et al., “Deinococcus radioduransDNA Increases the Radiation Resistance ofEscherichia coli”, Radiation Research 120., (1989),pp. 532-536.
Daly, Michael J., “Engineering Radiation-Resistant Bacteria For Environmental Biotechnology”,Current Opinion in Biotechnology, (2000),pp. 280-285.
Denardo, Diane A., et al., “Prediciton of Radiation Doses from Therapy Using Tracer Studies with Iodine-131-Labeled Antiobodies”,The Journal of Nuclear Medicine, vol. 37, (1996),pp. 1970-1975.
Galen, James E., et al., “Optimization of Plasmid Maintenance in the Attenuated Live Vector Vaccine StrainSalmonella typhiCVD 908-htrA”,Infection and Immunity., (Dec. 1999),6424-6433.
Haberkorn, U. , “Gene Therapy With Sodium/Iodide Symporter in Hepatocarcinoma”,Exp Clin Endocrinol Diabetes 109., (2001),pp. 60-62.
Hlavalty, J. , et al., “Construction and Testing of Gene Therapy Retroviral Vector Expressing Bacterial Cytosine Deaminase Gene”,Neoplasma 46., (1999),pp. 267-276.
Hoiseth, Susan K., et al., “Aromatic-DependentSalmonella typhimuriumAre Non-Virulent and Effective as Live Vaccines”,Naturevol. 291, (May 1981),pp. 238-239.
Huang, Min , et al., “Ectopic Expression of the Thyroperoxidase Gene Augments Radioiodide Uptake and Retention Mediated By the Sodium Iodide Symporter in Non-Small Cell Lung Cancer”,Cancer Gene Therapy, vol. 8., (2001),pp. 612-618.
Jakopitsch, Christa , et al., “Catalase-Peroxidase from Synechocystis Is Capable of Chlorination and Bromination Reactions”,Biochemical&Biophysical Research Comm 287, (2001),pp. 682-687.
Jones, Bradley D., et al., “Invasion bySalmonella typhimuriumIs Affected by the Direction of Flagellar Rotation”,Am Society for Microbiology, (Jun. 1992),pp. 2475-2480.
Lambin, P. , et al., “The Potential Therapeutic Gain of Radiation-Associated Gene Therapy With the Suicide Gene Cytosine Deaminase”,Int. J. Radiat. Biol., vol. 76, No. 3., (2000),pp. 285-293.
Lee, Catherine A., et al., “Identification of aSalmonella typhimuriumInvasion Locus by Selection for Hyperinvasive Mutants”,Proc. Nat'l Acad. Sci, USA, vol. 89., (Mar. 1992),pp. 1847-1851.
Levy, Orlie , et al., “Characterization of the Thyroid Na+/l- Symporter With An Anti-COOH Terminus Antibody”,Proc. Nat'l Acad. Sci. USA, vol. 94, pp. 5568-5573.
Macey, Daniel J., et al., “A Radioimmunoimaging and MIRD Dosimetry Treatment Planning Program for Radioimmunotherapy”,Nuclear Medicine&Biology, vol. 23., (1996),pp. 525-532.
Mandell, Robert B., et al., “Radioisotope Concentrator Gene Therapy Using the Sodium/Iodide Symportr Gene”,Cancer Research 59,, (Feb. 1999),pp. 661-668.
O'Callaghan, David , et al., “High Efficiency Transformation ofSalmonella typhimuriumandSalmonnela typhiby Electroporation”,Mol Gen Genet 223, (1990),pp. 156-158.
Pawleek, John M., et al., “Tumor-TargetedSalmonellaAs A Novel Anticancer Vector”,Cancer Research., (Oct. 1977),pp. 4537-4544.
Roy, Astrid M., et al., “Mutations in firA, Encoding the Second Acyltransferase in Lipopolysaccharide Biosynthesis, Affect Multiple Steps in Lipopolysaccharide Biosynthesis”,Journal of Bacteriology, (Mar. 1994),pp. 1639-1646.
Somerville, John E., et al., “A NovelEscherichia coliLipid A Mutant That Produces an Antiinflammatory Lipopolysaccharide”,The American Society for Clinical Investigation, Inc., (Jan. 1996),pp. 359-365.
Spitzweg, Christine , et al., “Analysis of Human Sodium Iodide Symporter Gene Expression in Extrathyroidal Tissues and Cloning of its Complementary Deoxyribonucleic Acids from Salivary Gland, Mammary Gland, and Gastric Mucosa”,Journal of Clinical Endocrinology and Metabolism, (1998),pp. 1746-1751.
Spitzweg, Christine , et al., “Approaches to Gene Therapy with Sodium/Iodide Symporter”,Exp Clinical Endocrinoll Diabetes 109, pp. 56-59.
Spitzweg, Christine , et al., “Prostate-Specific Antigen (PSA) Promoter-Driven Androgen-Indicible Expression of Sodium Iodide Symporter in Prostate Cancer Cell Lines”,Cancer Research 59, (May 1999),pp. 2136-2141.
Spitzweg, Christine , et al., “The Sodium Iodide Symportr and Its Potential Role in Cancer Therapy”,The Journal of Clinical Endocrinology and Metabolism, (2001),pp. 3327-3335.
Spitzweg, Christine , et al., “Treatment of Prostate Cancer by Radioiodine Therapy after Tissue-Specific Expression of the Sodium Iodide Symporter”,Cancer Research 60,, (Nov. 2000),pp. 6526-6530.
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MDS (Canada) Inc.
Navarro Mark
Schwegman, Lundberg, Woessner and Kluth P.A.
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