Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-04-21
1989-07-25
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31555
Patent
active
048514039
ABSTRACT:
The present invention relates to a method of potentiating radiation therapy using Co(III) complexes of water soluble, synthetic meso-substituted porphyrins. The method results in the sensitization of both well oxygenated (oxic) and oxygen deficient (hypoxic) tumor cells.
REFERENCES:
patent: 4727068 (1988-02-01), Abrams et al.
Biochemistry 1983, 22, 2406-2414.
Inorganico Chimica Acta Letters, 104 (1985) L25-27.
Journal of the American Chemical Society, (95:7) Apr., 1973.
Abrams Michael J.
Giandomenico Christen M.
Picker Donald H.
Vollano Jean F.
Gobrogge Roger
Johnson Matthey Inc.
Robinson Douglas W.
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