Radiation sensitization using texaphyrins

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 514 23, 514410, A61K 31555

Patent

active

058889973

ABSTRACT:
The invention relates to the field of radiation sensitizers and the use of texaphyrins for radiation sensitization and other conditions for which X-ray radiation has proven to be therapeutic.

REFERENCES:
patent: 4318825 (1982-03-01), Frame
patent: 4647447 (1987-03-01), Gries et al.
patent: 4835263 (1989-05-01), Nguyen et al.
patent: 4878891 (1989-11-01), Judy et al.
patent: 4880008 (1989-11-01), Lauffer
patent: 4883790 (1989-11-01), Levy et al.
patent: 4899755 (1990-02-01), Lauffer et al.
patent: 4915683 (1990-04-01), Sieber
patent: 4935498 (1990-06-01), Sessler et al.
patent: 4959363 (1990-09-01), Wentland
patent: 4977177 (1990-12-01), Bommer et al.
patent: 5021236 (1991-06-01), Gries et al.
patent: 5030200 (1991-07-01), Judy et al.
patent: 5041078 (1991-08-01), Matthews et al.
patent: 5141911 (1992-08-01), Meunier et al.
patent: 5162509 (1992-11-01), Sessler et al.
patent: 5242797 (1993-09-01), Hirschfeld
patent: 5252720 (1993-10-01), Sessler et al.
patent: 5256399 (1993-10-01), Sessler et al.
patent: 5272056 (1993-12-01), Burrows et al.
patent: 5272142 (1993-12-01), Sessler et al.
patent: 5292414 (1994-03-01), Sessler et al.
patent: 5302714 (1994-04-01), Sessler et al.
patent: 5369101 (1994-11-01), Sessler et al.
patent: 5371199 (1994-12-01), Therien et al.
patent: 5432171 (1995-07-01), Sessler et al.
patent: 5439570 (1995-08-01), Sessler et al.
patent: 5451576 (1995-09-01), Sessler et al.
patent: 5457183 (1995-10-01), Sessler et al.
patent: 5475104 (1995-12-01), Sessler et al.
patent: 5504205 (1996-04-01), Sessler et al.
patent: 5525325 (1996-06-01), Sessler et al.
patent: 5559207 (1996-09-01), Sessler et al.
patent: 5565552 (1996-10-01), Magda et al.
patent: 5567687 (1996-10-01), Magda et al.
patent: 5569759 (1996-10-01), Sessler et al.
patent: 5583220 (1996-12-01), Sessler et al.
patent: 5587371 (1996-12-01), Sessler et al.
patent: 5587463 (1996-12-01), Sessler et al.
patent: 5591422 (1997-01-01), Hemmi et al.
patent: 5594136 (1997-01-01), Sessler et al.
patent: 5595726 (1997-01-01), Magda et al.
patent: 5599923 (1997-02-01), Sessler et al.
patent: 5599928 (1997-02-01), Hemmi et al.
patent: 5601802 (1997-02-01), Hemmi et al.
patent: 5607924 (1997-03-01), Magda et al.
patent: 5622946 (1997-04-01), Sessler et al.
patent: 5632970 (1997-05-01), Sessler et al.
patent: 5633354 (1997-05-01), Magda et al.
Abid et al., "Lanthanide Complexes of Some Macrocyclic Schiff Bases Derived from Pyridine-2,6-dicarboxaldehyde and .alpha.,.omega.-Primary Diamines", Inorg. Chim. Acta, 95:119-125, 1984.
Acholla et al., "Binucleating Tetrapyrrole Macrocyles", J. Am. Chem. Soc., 107:6902-6908, 1985.
Acholla et al., "A Binucleating Accordian Tetrapyrrole Macrocycle", Tetrahedron Lett., 25:3269-3270, 1984.
Ansell, "X-Ray Crystal Structure of the Pentagonal Bipyramidal Nickel(11) Selective Stabilisation of the Nickel(1) Oxidation State by a Quinquedentate Macrocyclic Ligand", J. Chem. Soc., Chem. Commun. pp. 546-547, 1982.
Bauer et al., "Sapphyrins: Novel Aromatic Pentapyrrolic Macrocycles", J. Am. Chem. Soc., 105:6429-6436, 1983.
Broadhurst et al., "Preparation of Some Sulphur-containing Polypyrrolic Macrocycles. Sulphur Extrusion from a meso-Thiaphlorin", J. Chem. Soc., Chem. Commun. pp. 807-809, 1970.
Broadhurst et al., "18- and 22-.pi.-Electron Macrocycles Containing Furan, Pyrrole, and Thiopen Rings", J. Chem. Soc., Chem. Commun. pp. 1480-1482, 1969.
Broadhurst et al., "New Macrocyclic Aromatic Systems Related to Porphins", J. Chem. Soc., Chem. Commun. pp. 23-24, 1969.
Broadhurst et al., "The Synthesis of 22 .pi.-Electron Macrocycles. Sapphyrins and Related Compounds", J. Chem. Soc. Perkin Trans., 1:2111-2116, 1972.
Cuellar et al., "Synthesis and Characterization of Metallo and Metal-Free Octaalkylphthalocyanines and Uranyl Decaalkysuperphthalocyanines", Inorg. Chem., 20:3766-3770, 1981.
Day et al., "Large Metal Ion-Centered Template Reactions. A Uranyl Complex of Cyclopentakis (2-iminoisoindoline)", J. Am. Chem. Soc., 97:4519-4527, 1975.
De Cola et al., "Hexaaza Macrocyclic Complexes of the Lanthanides", Inorg. Chem., 25:1729-1732, 1986.
Dougherty, "Photosensitizers: Therapy and Detection of Malignant Tumors", Photochem. Photobiol., 45:879-889, (1987).
Gosmann et al., "Synthesis of a Fourfold Enlarged Porphyrin with an Extremely Large, Diamagnetic Ring-Current Effect", Angew. Chem., Int. Ed Engl., 25:1100-1101, (1986).
Gossauer, "Syntheses of Some Unusual Polypyrrole Macrocycles", Bull. Soc. Chim. Belg., 92:793-795, (1983).
Knubel et al., "Biomimetic Synthesis of an Octavinylogous Porphyrin with an 27:1170-1172, 1988.
Lauffer, "Paramagnetic Metal Complexes as Water Proton Relaxation Agents for NMR Imaging: Theory and Design", Chem. Rev., 87:901-927, 1987. Tetrapyrrolic Annulene", J. Org. Chem., 52:710-711, 1987.
Marks et al., "Large Metal Ion-Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1-iminoisoindolinato) uranium (VI) and Its Derivatives", J. Am. Chem. Soc., 100:1695-1705, 1978.
Rexhausen et al., "The Synthesis of a New 22 .pi.-Electron Macrocycle: Pentaphyrin", J. Chem. Soc., Chem. Commun., p. 275, 1983.
Sessler et al., "Synthesis and Crystal Structure of a Novel Tripyrrane-Containing Porphyrinogen-like Macrocycle", J. Org. Chem., 52:4394-4397, 1987.
Sessler et al., "The Coordination Chemistry of Planar Pentadentate Porphyrin-Like Ligands", Comm. Inorg. Chem., 7:333-350, 1988.
Sessler et al., "The Synthesis and Structure of a Novel 22 .pi.-Electron Aromatic Pentadentate Macrocyclic Ligand: An Expanded Porphyrin", Toronto ACS Meeting, Jun. 1988. USA.
Sessler et al., "A Water-Stable Gadolinium (III) Complex Derived from a New Pentadentate", Chem. Absts., 111:720, abstract No. 125716e, Oct. 2, 1989.
Stinson, "Unusual Porphyrin Analog Promises Many Applications", Chemical and Engineering News, pp. 26-27, Aug. 8, 1988.
Sessler et al., "Tripyrroledimethine-derived (Texaphyrin-type) Macrocycles: Potential Photosensitizers Which Absorb in the Far-red Spectral Region", SPIE, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanism and Technique, 1426:318-329, 1991.
Sessler et al., "`Texaphyrin`: A Novel 22 .pi.-Electron Aromatic Pentadentate Macrocyclic Ligand", ACS meeting, Los Angeles, Sep. 1988.
Sessler and Burrell, "Expanded Porphyrins," Topics in Current Chemistry, 161:180-273, 1991.
Sessler et al., "Synthesis and Structural Characterization of Lanthanide(III) Texaphyrins," Inorganic Chemistry, 32(14):3175-3187, 1993.
"2-Athylamino-2-methyl-propanol-(1)", Beilstein's Handbuch, 4:785, 1950.
"Tentative Rules for Carbohydrate Nomenclature Part 1 (1969)," Handbook of Biochemistry and Molecular Biology, 3rd ed., Fasman, Ed., CRC Press, Cleveland, Ohio, pp. 100-102.
Sessler et al., "Preparation of Lanthanide (III) Texaphyrin Complexes and Their Applications to Magnetic Resonance Imaging and Photodynamic Therapy," Abstracts of Papers, Part 1, 204th ACS National Meeting, Aug. 23-28, 1992, Washington, DC.
Sessler et al., "Synthesis and Applications of Schiff-Base Derived Expanded Porphyrins," Abstracts of Papers, Part 1, 204th ACS National Meeting, Aug. 23-28, 1992, Washington, DC.
Sessler, Jonathan L., "Texas-Sized Molecule," Discovery, 13(1):44-49, 1993.
Sessler et al., "Photodynamic Inactivation of Enveloped Viruses Using Sapphyrin, .alpha. 22 .pi.-Electron Expanded Porphyrin: Possible Approaches to Prophylactic Blood Purification Protocols," SPIE Photodynamic Therapy: Mechanisms II. 1203:233-245, 1990.
Maiya et al., "Ground- and Excited-State Spectral and Redox Properties of Cadmium(II) Texaphyrin," Journal of Physical Chemistry, 93(24):8111-8115, 1989.
Sessler et al., "An Expanded Porphyrin: The Synthesis and Structure of a New Aromatic Pentadentate Ligand", J. Am. Chem. Soc., 110:5586-5588, 1988.
Tweedle et al., "Principles of Contrast-Enhanced MRI", in Magnetic Resonance Imaging, 2nd ed. Partain, et al, Eds., W. B. Saunders: Philadelphia, vol. I (1988) 793-809.
Vogel et al., "Porphycene--a Novel Porphin Isomer", Angew. Chem., Int. Ed. Engl., 25:257-259, 1986.
Vogel et al., "2,7,12,17-Tetrapropylporphycene--Counterpart of Oc

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Radiation sensitization using texaphyrins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Radiation sensitization using texaphyrins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radiation sensitization using texaphyrins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1215222

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.