Radiation-protective phospholipid and method

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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558169, 558186, A61K 9127

Patent

active

061655015

ABSTRACT:
Ether-linked phospholipids, derivatized at the polar head group with polyethylene glycol chains having molecular weights greater than 2,000 daltons, are disclosed. Lipid bilayers containing these phospholipids show high oxidative stability. Also disclosed is the use of PEG-derivatized ether-linked lipids in moisturizing and radiation-protective cosmetic compositions.

REFERENCES:
patent: 4426330 (1984-01-01), Sears
patent: 4534899 (1985-08-01), Sears
patent: 4772471 (1988-09-01), Vanlerberghe et al.
patent: 5013556 (1991-05-01), Woodle
patent: 5190915 (1993-03-01), Behan et al.
patent: 5252555 (1993-10-01), Dartnell et al.
patent: 5817856 (1998-10-01), Tivosh
Allen, T.M., "Stealth Liposomes: Five Years On," J. Liposome Research 2 (3) :289-305 (1992).
Brezesinski, G., et al., "Influence of Ether Linkages on the Structure of uble-Chain Phospholipid Monolayers," Chemistry and Physics of Lipids 76:145-157 (1995).
Hing, F.S., et al., "Structure and Interactions of Ether-and Ester-Linked Phosphatidylethanolamines," Biochemistry 30(37):9007-9015 (1991).
Hristova, K., and Needham, D., "Phase Behavior of a Lipid/Polymer-Lipid Mixture in Aqueous Medium," Macromolecules 28:991-1002 (1995).
Kim, J.T., et al., "Gel Phase Polymorphism in Ether-Linked Dihexadecylphosphatidylcholine Bilayers, " Biochemistry 26:6592-6598 (1987).
Kim, J.T., et al., "Bilayer Interactions of Ether-and Ester-Linked Phospholipids: Dihexadecyl-and Dipalmitoylphosphatidylcholines, " Biochemistry 26:6599-6603 (1987).
Lindh, I., and Stawi.sub.- ski, J., "A General Method for the Synthesis of Glycerophophospholipids and Their Analogues via H-Phosphonate Intermediates," J. Org. Chem. 54:1338-1342.
Ukawa, K., et al., "Synthesis and Antitumor Activity of New Amphiphilic Alkylglcerolipids Substituted with a Polar Head Group, 2-(2-Trimethylammonioethoxy) ethyl or a Congeneric Oligo (ethyleneoxy) ethyl Group," Chem. Pharm. Bull. (12) :3277-3285 (1989.
Wheeler, J.J., et al., "Polyethylene Glycol Modified Phospholipids Stabilize Emulsions Prepared from Triacylglycerol," J. Pharmaceutical Sciences 83(11) :1558-1564 (1994).

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