Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-04-05
2011-04-05
Fetterolf, Brandon J (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07919525
ABSTRACT:
The present invention relates to methods for the prevention and treatment of a mammal from radiation-induced internal injury using γ-tocotrienol, α-tocopherol succinate or γ-tocotrienol succinate. Specifically, the present invention relates to methods for preventing and treating radiation-induced injuries in a mammal by (1) subcutaneous, intramuscular, intraperitoneal, or intravascular injection of a therapeutically effective amount of γ-tocotrienol; or (2) oral administration of a therapeutically effective amount of α-tocopherol succinate or γ-tocotrienol succinate or both.
REFERENCES:
patent: 5376361 (1994-12-01), Perricone
patent: 5709868 (1998-01-01), Perricone
patent: 5840734 (1998-11-01), Bernstein
patent: 6251878 (2001-06-01), Strickland et al.
patent: 6716451 (2004-04-01), Udell et al.
patent: 7449451 (2008-11-01), Prasad et al.
patent: 2003/0064955 (2003-04-01), Prasad et al.
patent: 1178675 (1998-04-01), None
patent: 4405545 (1995-08-01), None
patent: 2781156 (2000-01-01), None
patent: 05213763 (1993-08-01), None
patent: 2002-521321 (2002-07-01), None
patent: 2002-332231 (2002-11-01), None
patent: 03/039452 (2003-05-01), None
Jarrett et al. (Radiation Measurements 42(6-7) 2007, 1063-1074).
Karjala, My battle with stage IV lung cancer, 23 pages, 2000.
Blumenthal et al Proceedings of the American association for Cancer Research, Abstract, vol. 40, #4227, Mar. 1999.
Moss (1981), International Union of Pure and Applied Chemistry, 6 pages.
Clinical trials, 2005, 4 pages.
Weiss, Environmental Health Perspectives 15(6) 1473-1478, (1997).
Moller , The FASEB J. 16, 45-53, (2002).
Ross et al. Scanning Microsc (1990) Abstract Only.
Weber, et al., “Efficacy of Topically Applied Tocopherols and Tocotrienols in Protection of Murine Skin From Oxidative Damage Induced by UV-Irradiation”, Free Radical Biology and Medicine, vol. 22, No. 5, pp. 761-769, Abstract only, 1997.
Kamal-Eldin, et al., “The Chemistry and Antioxidant Properties of Tocopherols and Tocotrienols,” Lipids, vol. 31, No. 7, pp. 671-701 (1996).
Ahn, et al., “γ-tocotrienol inhibits nuclear factor-κB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis,” Journal of Biological Chemistry, vol. 282, No. 1, pp. 809-820 (2007).
Singh, et al., “Induction of Cytokines by Radioprotective Tocopherol Analogs,” Experimental and Molecular Pathology, vol. 81, pp. 55-61 (2006).
Sen, et al., “Tocotrienols: Vitamin E beyond tocopherols,” Life Sciences, vol. 78, pp. 2088-2098 (2006).
Supplementary European Search Report, dated Oct. 10, 2007, issued in European application No. 04711839.3.
Journal of Pharmacological Sciences, “The effect of vitamin E analogs against H2O2-induced neurotoxin in striate body,” 117(2):33, (Feb. 1, 2001), partial translation (1 page).
Kamat et al. “Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria,” Neuroscience Letters, 195:179-182 (1995) (4 pages).
Podda et al., “A combination of vitamin E homologues applied to skin protects against ultraviolet-irradiation-induced damage,” Dept. Molecular and Cell Biology, University of California Berkeley, 106(4):919 (Apr. 1996) (1 page).
Sugiyama et al., “Effect of vitamin E on cytotoxicity, DNA single strand breaks, chromosomal aberrations, and mutation in Chinese hamster V-79 cells exposed to ultraviolet-B light,” Photochemistry and Photobiology, 56(1):31-34 (1992) (4 pages).
Kumar, et al., “Nutritional Approaches to Radioprotection: Vitamin E”, Military Medicine, 167 Suppl., 1:57-59 (2002) (5 pages).
Kumar K. Sree
Papas Andreas
Seed Thomas M.
Srinivasan Venkataraman
Fetterolf Brandon J
Gembeh Shirley V
Henry M. Jackson Foundation for the Advancement of Military Medi
Wilmer Cutler Pickering Hale and Dorr LLP
LandOfFree
Radiation protection by gamma-tocotrienol does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Radiation protection by gamma-tocotrienol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radiation protection by gamma-tocotrienol will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2670879