Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1998-07-09
2000-12-26
Elliott, George C.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
264473, 264488, 600 1, 536 231, 536 245, 514 44, A61K 5100, C07H 2104, H05B 600, A61N 500
Patent
active
06165440&
ABSTRACT:
The present invention discloses a method/system utilizing interaction of electromagnetic pulses or ultrasonic radiation with nano- and microparticles for enhancement of drug delivery in solid tumors. The particles can be attached to antibodies directed against antigens in tumor vasculature and selectively delivered to tumor blood vessel walls. Cavitation induced by ultrasonic waves or local heating of the particles by pulsed electromagnetic radiation results in perforation of tumor blood vessels, microconvection in the interstitium, and perforation of cancer cell membrane, and therefore, provides enhanced delivery of macromolecular therapeutic agents from blood into cancer cells with minimal thermal and mechanical damage to normal tissues.
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Board of Regents , The University of Texas System
Elliott George C.
Epps Janet
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