RAD51 polypeptides and uses thereof

Details RAD51 polypeptides and uses thereof RAD51 polypeptides and uses thereof

2006-04-25

2006-04-25

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

07034117

ABSTRACT:
The invention provides isolated RAD51C nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering RAD51C levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions.

REFERENCES:
patent: 4665160 (1987-05-01), Seeburg
patent: 5661021 (1997-08-01), Buchert et al.
patent: WO 97/41228 (1997-11-01), None
Rounsley et al, Jan. 1998, Putative DNA Repair Protein (RAD57).
Reiss et al, RecA protein stimulates homologous recombination in plants, 1996, Proc. Natl. Acad., vol. 93, pp. 3094-3098.
Reiss et al, “RecA stimulates sister chromatid exchange and the fidelity of double-strand break repair, but not gene targeting, in plants transformed by Agrobacterium”, 2000, PNAS vol. 97 No. 7 pp. 3358-3363.
Dosanjh et al, Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes, 1998, Nucleic Research, 1998, vol. 26 No. 5, pp. 1179-1184.
Hill et al, Functional Analysis of Conserved Histidines in ADP-Glucose Proyphosphorylase fromEscherichia coli, 1998, Biochemical and Biophysical Research Comm. vol. 244, pp. 573-577.
Broun et al, Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying chemical Diversity of Plant Lipids, 1998, Science vol. 282, pp. 1315-1317.
Bowie e al, “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions”, 1990, Science vol. 247, pp. 1306-1310.
Gordon-Kamm, “Transformation of Maize Cells and Regeneration of Fertile Transgenic Plants”, 1990, The Plant Cell. vol. 2, pp. 603-618.
Lazar et al, Transforming Growth Factor x: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activies, 1988, Molecular and Cellular Biology vol. 8 No. 3, pp. 1247-1252.
Shinohara et al., Homologous recombination and the roles of double-strand breaks, Trends in Biochem. Sci. 237:387-391 (1995).
Ogawa et al., Rec-A-like Recombination Proteins in Eukaryotes: Functions and Structures of RAD51 Genes, Cold Spring Harbor Symposia on Quantitative Biology, 58:567-576 (1993).
Johnson et al., Functional Differences and Interactions among the Putative RecA Homologs Rad51, Rad55, and Rad57, Mol. Cell. Biol. 15(9):4843-4850 (1995).
Kans et al., Nucleotide sequence of the RAD57 gene ofSaccharomyces cerevisiae, Gene 105:139-140 (1991).
Jeggo, P.A., Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian Cells, Radiation Research 150 (Suppl.) S80-S91 (1998).
Sung, P., Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase, Genes & Development 11:1111-1121 (1997).
Sung, P., Catalysis of ATP-Dependent Homologous DNA Pairing and Strand Exchange by Yeast RAD51 Protein, Science 265:1241-1243 (1994).
Sung et al., DNA Strand Exchange Mediated by a RAD51-ssDNA Nucleoprotein Filament with Polarity Opposite to That of RecA, Cell 82:453-461 (1995).
Vispe et al., Mammalian Rad51 protein: A RecA homologue with pleiotropic functions, Biochimie 79:587-592 (1997).
Yoshimura et al., Cloning and sequence of the human RecA-like gene cDNA, Nuc. Acids Res. 21(7):1665 (1993).
Rice et al., Isolation of human and mouse genes based on homology to REC2, recombinational repair gene from the fungus Ustilago maydis, Proc. Natl. Acad. Sci. USA 94:7417-7422 (1997).
Albala et al., Identification of a Novel Human RAD51 Homolog, RAD51B, Genomics 46:476-479 (1997).
Dosanjh et al., Isolation and characterization of RAD51C, a new human member of the RAD 51 family of related genes, Nuc. Acids Res. 26(5):1179-1184 (1998).
Pittman et al., Identification, Characterization, and Genetic Mapping of Rad51d, a New Mouse and Human RAD51/RecA-Related Gene, Genoimics 49:103-111 (1998).
Tsuzuki et al., Targeted disruption of the Rad51 gene leads to lethality in embryonic mice, Proc. Natl. Acad. Sci. USA 93:6236-6240 (1996).
Xia et al., Elevated Recombination in Immortal Human Cells is Mediated by HsRAD51 Recombinase, Mol. Cell. Biol. 17(12):7151-7158 (1997).
Vispe et al., Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation, Nuc. Acids Res. 26(12):2859-2864 (1998).
Lin et al.,Arabidopsis thalianachromosome II section 242 of 255 of the complete sequence. Sequence from clones T14P1, F4L23, EMBL Database Entry AC002387; Accession No. AC002387 (1999).
Thacker et al., A surfelt of RAD51-like genes, Trends in Genetics 15(5):166-168 (1999).
Shoemaker et al., Public Soybean EST Project; sf36d09.x1 Gm-c1028 Glycine max cDNA clone Genome Systems Clone ID: Gm-c1028-2058 3′ similar to TR:022144 022144 Putative DNA Repair Protein; mRNA, EMB Database Entry AW310460; Accession No. AW310460 (2000).

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