Rad23 genes and uses thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...

Reexamination Certificate

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C530S370000, C530S350000, C435S183000, C435S194000, C536S023100, C800S295000

Reexamination Certificate

active

06878809

ABSTRACT:
The invention provides isolated Rad23 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering Rad23 concentration and/or composition of plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions.

REFERENCES:
Doerks (TIG 14, No. 6: 248-250, Jun. 1998),.*
Smith et al (Nature Biotechnology 15:1222-1223, Nov. 1997.*
, Brenner (TIG 15, 4:132-133, Apr. 1999).*
Borks (TIG 12, 10:425-427, Oct. 1996).*
Broun et al (Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids, Science 282, pp. 1315-1317, Nov. 1998).*
Van de Loo et al (An oleate 12-hydroxylase fromRicinus communis L.is a fatty acyl desaturase homolog, Proc, Natl. Acad. Sc USA 92, 6743-6747, Jul. 1995).*
Watkins et al., The Saccharomyces cerevisiae DNA Repair Gene RAD23 Encodes a Nuclear Protein Containing a Ubiquitin-Like Domain Required for Biological Funcation, Mol. Cell. Biol. 13(12):7757-7765 (1993).
Prakash et al., DNA Repair Genes and Proteins of Saccharomyces Cerevisiae, Ann. Rev. Genet. 27:33-70 (1993).
Mueller et al., Rad23 is Required for Transcription-Coupled Repair and Efficient Overall Repair in Saccharomyces cerevisiae, Mol. Cell. Biol 16(5):2361-2368 (1996).
Van Der Spek et al., Cloning, Comparative Mapping, and RNA Expression of the Mouse Homologues of the Saccharomyces cerevisiae Nucleotide Excision Repir Gene, Genomics 31:20-27 (1996).
Wang et al., The RAD7, RAD16, and RAD23 Genes of Saccharomyces cerevisiae; Requirement for Transceiption-Independent Nucleotide Excision Repair In Vitro and Interactions between the Gene Products, Mol. Cell. Biol 17(2):635-643 (1997).
Sugasawa et al., Two Human Homologs of Rad23 Are Functionally Interchangeable in Complex Formation and Stimulation of XPC Repair Activity, Mol. Cell. Biol. 17(12):6924-6931 (1997).
Schultz et al., Characterization and expression of a rice Rad23 gene, Plant Mol. Biol. 34:557-562 (1997).
Schauber et al., Rad23 links DNA repair to the ubiquitin/proteasome pathway, Nature 391:715-718 (1998).
Gragerov et al., HHR23A, the Human Homologue of the Yeast Repair Protein RAD23, Ineracts Specifically with Vpr Protein and Prevents Cell Cycle Arrest but Not the Transcriptional Effects of Vpr, Virology 245:323-330 (1998).
Sturm et al., Two isoforms of plant RAD23 complement a UV-sensitive rad23 mutant in yeast, Plant Journal 13(6):815-821 (1998).
Baysdorfer, C., EMBL Accession No. AA661449, Zea mays cDNA clone csuh00631 5′ similar to RAD 23, (1997).
Walbot, V., EMBL Accession No. Al881646, Maize ESTs from various cDNA libraries (1999).

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