Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1992-11-04
1994-01-11
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
548571, 548572, 549 78, 549 79, 549498, 549499, 558354, 560 10, 560 15, 560 17, 560 51, 560 56, 560 60, 560 61, 560100, 560102, 560105, 560121, 560123, 560124, 560125, 560128, 560152, 560226, 560227, 560265, 564123, 564162, 564169, 564180, 564183, 564189, 564190, 564209, 568420, 568426, 568440, 568442, 568446, 568449, 568495, C07B 5500, C07D20704, C07D33316
Patent
active
052783383
ABSTRACT:
A method for racemizing an optically active carboxylic acid, or ester thereof, of the formula: ##STR1## where R.sub.1 is hydrogen, hydroxy, halo, cyano, C.sub.1 to C.sub.6 linear or branched alkoxy, amino or substituted amino or the group ##STR2## is nitrile; R.sub.2, R.sub.3 and R.sub.4 are different and are hydrogen or C.sub.1 to C.sub.6 linear or branched alkyl, C.sub.1 to C.sub.6 linear or branched haloalkyl, aralkyl, cycloalkyl, alkyl substituted cycloalkyl, C.sub.6 to C.sub.10 aryl, C.sub.1 to C.sub.6 linear or branched alkoxy, C.sub.6 to C.sub.10 aryloxy, C.sub.1 to C.sub.6 alkylthio, C.sub.3 to C.sub.8 cycloalkylthio, C.sub.6 to C.sub.10 arylthio, C.sub.6 to C.sub.10 arylcarbonyl, C.sub.4 to C.sub.8 cycloalkenyl, trifluoromethyl, halo, C.sub.4 to C.sub.5 heteroaryl, C.sub.10 to C.sub.14 aryl, or biphenyl unsubstituted or substituted with methyl or halo, comprising heating said optically active carboxylic acid or ester thereof in the presence of water at a temperature of from about 40.degree. C. to about 200.degree. C. in the presence of a catalytically effective amount of a compound of the formula M(XO).sub.n where M is an alkali or alkaline earth metal, X is halogen, where n is 1 or 2 for a time sufficient to racemize said carboxylic acid or ester thereof.
REFERENCES:
patent: 4767880 (1988-08-01), Wullbrandt et al.
patent: 4769486 (1988-09-01), Harada et al.
patent: 5145992 (1992-09-01), Mueller et al.
Clarke Vera C.
Dees Jos,e G.
Ethyl Corporation
Hammond Richard J.
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