Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1997-10-22
1998-12-08
Barts, Samuel
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
560 56, 560105, C07C 5500
Patent
active
058472029
ABSTRACT:
Optically active carboxylic acids, salts or esters, such as the profen-type compounds, are racemized in the presence by nitrogenous bases such as methylbenzylamine by heating an aqueous solution of such optically active compounds in the presence of a suitable excess of an alkali metal hydroxide relative to the amount optically active carboxylic compound present in the solution. The process not only enables conversion of inactive or undesirable enantiomers of compounds such as naproxen or ibuprofen into a usable, desirable enantiomers in an efficient and economical manner, but avoids conversion of the nitrogenous base into amide. Thus the deleterious consequences of amide formation are avoided.
REFERENCES:
patent: 3686183 (1972-08-01), Dyson
patent: 4245116 (1981-01-01), Ohno et al.
patent: 4246164 (1981-01-01), Felder et al.
patent: 4851444 (1989-07-01), Sunshine et al.
patent: 4877620 (1989-10-01), Loew et al.
patent: 5015764 (1991-05-01), Manimaran et al.
patent: 5221765 (1993-06-01), Patil et al.
patent: 5235095 (1993-08-01), Kadkhodayan et al.
patent: 5254720 (1993-10-01), Wu
patent: 5315026 (1994-05-01), Wu
patent: 5332834 (1994-07-01), Bhattacharya et al.
Manimaran Thanikavelu
Phan Hao V.
Young Robert E.
Zumstein Ronald C.
Albemarle Corporation
Barts Samuel
Pippenger Philip M.
LandOfFree
Racemization process for optically active carboxylic acids or sa does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Racemization process for optically active carboxylic acids or sa, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Racemization process for optically active carboxylic acids or sa will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-179202