Racemization process

Details Racemization process Racemization process

1992-10-01

1994-01-11

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560231, 560248, 562401, C07C 6976, C07C 5110

Patent

active

052783340

ABSTRACT:
A method for racemizing an optically active aliphatic carboxylic acid, or ester thereof, of the formula: ##STR1## where R.sub.1 is hydrogen or C.sub.1 to C.sub.6 linear or branched alkyl; R.sub.2, R.sub.3 and R.sub.4 are different and are hydrogen or C.sub.1 to C.sub.6 linear or branched alkyl, C.sub.1 to C.sub.6 linear or branched haloalkyl, aralkyl, cycloalkyl, alkyl substituted cycloalkyl, C.sub.6 to C.sub.10 aryl, C.sub.1 to C.sub.6 linear or branched alkoxy, C.sub.6 to C.sub.10 aryloxy, C.sub.1 to C.sub.6 alkylthio, C.sub.2 to C.sub.8 cycloalkylthio, C.sub.6 to C.sub.10 arylthio, C.sub.6 to C.sub.10 arylcarbonyl, C.sub.4 to C.sub.8 cycloalkenyl, trifluoromethyl, halo, C.sub.4 to C.sub.5 heteroaryl, C.sub.10 to C.sub.14 aryl, or biphenyl unsubstituted or substituted with methyl or halo, comprising heating said optically active carboxylic acid, ester or salt thereof at a temperature of from about 100.degree. C. to about 400.degree. C. at a hydrogen pressure of less than 40 atm in which palladium has a valence of 0-2 for a time sufficient to racemize said carboxylic acid, ester or salt thereof.

REFERENCES:
patent: 4515811 (1985-05-01), Holton
patent: 4723033 (1988-02-01), Erickson
patent: 4724102 (1988-02-01), Cannata et al.

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