Racemization of precursors to levobupivacaine and analogues ther

Details Racemization of precursors to levobupivacaine and analogues ther Racemization of precursors to levobupivacaine and analogues ther

1999-02-12

2000-12-05

Chang, Celia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562401, C07D21140

Patent

active

061569003

ABSTRACT:
A process for the preparation of optically-enriched pipecolic acid as a salt with an optically-active acid, comprises asymmetric transformation of pipecolic acid, as a racemic mixture of a mixture enriched in the opposite enantiomer from that desired, with the optically-active acid in a solvent comprising an acid that causes racemisation, in the absence of aldehyde.

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Chenault, H. K., et al. (1989) "Kinetic Resolution of Unnatural and Rarely Occurring Amino Acids: Enantioselective Hydrolysis of N-acyl Amino Acids Catalysed by Acylase I" Journal of the American Chemical Soc. 111(16):6354-6364.

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