Racemization of an enantomerically enriched .alpha.-aryl carboxy

Details Racemization of an enantomerically enriched .alpha.-aryl carboxy Racemization of an enantomerically enriched .alpha.-aryl carboxy

1992-12-02

1994-07-26

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562401, 562490, 562492, 562496, C07D23364, C07B 5500, C07B 5700, C07C 51487

Patent

active

053328345

ABSTRACT:
There is disclosed and claimed a process whereby S(+)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity of L-lysine is not more than about a molar equivalent of the quantity of S(+)-ibuprofen in the ibuprofen enantiomeric mixture. The mother liquors after separating the above salt are enriched in R-ibuprofen which is racemized by a novel thermal racemization process and may then be recycled.

REFERENCES:
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patent: 4946997 (1990-08-01), Larsen et al.
patent: 4994604 (1991-02-01), Tung et al.
patent: 5015764 (1991-05-01), Manimaran et al.
patent: 5221765 (1993-06-01), Patil et al.

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