Racemization of an .alpha.-methyl-.beta.-acylthiopropionic acid

Details Racemization of an .alpha.-methyl-.beta.-acylthiopropionic acid Racemization of an .alpha.-methyl-.beta.-acylthiopropionic acid

1981-07-02

1983-10-25

Ford, John M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C153023

Patent

active

044118368

ABSTRACT:
This invention relates to a process for the optical resolution of DL-.alpha.-methyl-.beta.-acylthiopropionic acids of the formula [I], ##STR1## wherein R is a lower alkyl group having 1-4 carbon atoms, phenyl or substituted phenyl bearing methyl or chloro radical; a method for the racemization of an optically active .alpha.-methyl-.beta.-acylthiopropionic acid of the formula [Ia], ##STR2## wherein R is as defined above; and a process for the synthesis of captopril of the formula [II], ##STR3## using the D-acid [Ia] as an intermediate.

REFERENCES:
patent: 4297282 (1981-10-01), Ohashi et al.

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