Racemization free attachment of amino acids to a solid phase

Details Racemization free attachment of amino acids to a solid phase Racemization free attachment of amino acids to a solid phase

1989-01-06

1993-02-16

Cashion, Jr., Merrell C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548496, 548535, 5483114, 560 24, 560 27, 560 29, 560 30, 560 31, 560 32, 560 33, 562575, 562560, 562561, 562573, 562571, 562557, 562563, 562559, 562445, 562567, C07D23364, C07C26100

Patent

active

051872706

ABSTRACT:
This invention pertains to amino acids attached to a solid support in a racemization free manner and to a method of covalently linking amino acids to solid supports for use in solid phase peptide syntheses.

REFERENCES:
Albericio et al. Int'l J. Peptide Prot. Res. vol. 26 (1985) pp. 92-97.
Bernatowicz, M. S. et al., Tetrahedron Letters, 30:4341-4344 (1989).
Merrifield, R. B., J. Am. Chem. Soc., 85:2149-2154 (1963).
Atherton, E. et al., J. C. S. Chem. Commun., 336-337 (1981).
Sieber, P. Tet. Lett., 28:6147-6150 (1987).
Kirstgen, R. et al., J. Chem. Soc., Chem. Commun., 1870-1871 (1987).
Mitchell, A. R. et al., J. Org. Chem., 43:2845-2852 (1978).
Wang, S. S. et al., J. Org. Chem., 42:1286-1290 (1977).
Colombo, R. et al., Int. J. Peptide Protein Res., 21:118-126 (1983).
Dhaon, M. K. et al., J. Org. Chem., 47:1962-1965 (1981).
Sheppard, R. C. and B. J. Williams, Int. J. Peptide Protein Res., 20:451-454 (1982).
Matsueda, G. R. and E. Haber, Anal. Biochem., 104:215-227 (1980).
Atherton, E. et al., J. Chem. Soc., Perkin Trans I, 538-546 (1981).
Mitchell, A. R. et al., J. Am. Chem. Soc., 98:7357-7362 (1976).
Tam, J. P. et al., Synthesis, 955-957 (1979).
Tjoeng, F. S. and G. A. Heavner, Synthesis, 897-899 (1981).
Plaue, S. and D. Heissler, Tetrahedron Letters, 28:1401-1404 (1987).
Gisin, B. F., Helevetica Chemica Acta, 56:1476-1482 (1973).
Horiki, K. et al., Chem. Letters, 165-168 (1978).
Milligen Technical Bulletin for Pepsyn KA.TM..
Arshady, R. et al., J. Chem. Soc. Perkin Trans 1, 529-537 (1981).
Atherton, E. et al., J. C. S. Chem. Comm., 1151 (1981).
MilliGen PepSynthesizer.TM. Model 9050 Operation Manual, Chapter 3.

Affiliated with

Also associated with

Rating

Racemization free attachment of amino acids to a solid phase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Racemization free attachment of amino acids to a solid phase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Racemization free attachment of amino acids to a solid phase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2148816